Lack of Association between the MiR146a Polymorphism and Susceptibility to Thai Childhood Acute Lymphoblastic Leukemia

Chansing, Kochpinchon; Pakakasama, Samart; Hongeng, Suradej; Thongmee, Acharawan; Pongstaporn, Wanida

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자료유형: 학술저널

저자정보: Chansing, Kochpinchon (Department of Biomedical Science, Faculty of Science, Rangsit University) Pakakasama, Samart (Hematology Unit, Pediatric Departments, Faculty of Medicine, Ramathibodi Hospital) Hongeng, Suradej (Hematology Unit, Pediatric Departments, Faculty of Medicine, Ramathibodi Hospital) Thongmee, Acharawan (Microbiology unit, Department of Biomedical Science, Faculty of Science, Rangsit University) Pongstaporn, Wanida (Pathobiology Unit, Department of Biomedical Science, Faculty of Science, Rangsit University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제5호

발행연도: 2016.1

수록면: 2,435 - 2,438 (4page)

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Background: MiRNAs, small non coding RNAs, play a role in the regulation of hematopoiesis, with effects on cell growth, differentiation, and apoptosis. In addition, MiRNAs are thought to play an important role in tumorigenesis. The miR146a G>C polymorphism can lead to alteration of miR146 expression, which appears to be associated with development and progression of several cancers. This study aimed to investigate the association of the miRNA146a (rs2910164) G>C polymorphism and susceptibility to childhood acute lymphoblastic leukemia (ALL) and clinical outcomes. Materials and Methods: Totals of 100 childhood ALL patients and 200 healthy children were studied for miR146a polymorphisms using polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP). Results: The frequency of the miR146a G allele in controls was 0.40 compared with 0.38 in ALL patients. There was no association between miRNA146a (rs2910164) G>C polymorphism and susceptibility to childhood ALL (OR=1.484, 95%CI=0.712-3.093, p=0.290). Moreover, the frequencies of miR146a (rs2910164) G>C polymorphism were not associated with demographic data and clinical outcomes in ALL cases. Conclusions: The miRNA146a polymorphism was not significantly associated with susceptibility to Thai childhood ALL or any clinico-pathological variables.

#Acute lymphoblastic leukemia #miRNA146a #polymorphism #susceptibility

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