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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 71 - 78 (8page)
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Objective : The purpose of the study was to identify expression profiling of miRNAs associated with cancers after treating allergen-removed Rhus Verniciflua Stokes and allergen-removed Rhus Verniciflua Stokes fumigaed Angelica gigas on leukemia cell lines. Methods : miRNA expression has been analyzed using miRNA array method through denaturation and hybridization after isolating the total RNA from leukemic cell line treated with 100 ㎍/㎖ of aRVS and aRVS-A each. Microarray expressions were interpreted as 'significant' on miRNAs when decreased less than 0.5 fold or increased more than 1.5 fold compared with the control group. Results : Among 158 miRNAs in total, 32 miRNAs were significantly presented in miRNAs expression. miRNA has been activated with a variety of genes for predicted targets, and the overexpressed miRNAs were categorized according to proliferation and metastasis of cancer in this study. The findings were reported that seven miRNAs (let-7b, miR-193a-5p, 296-3p, 26a, 22, 124a, 92b) showed significant expressions on proliferation and growth, seven miRNAs (miR-193a-5p, 26a, 200c, 183, 124a, 198, 210) presented meaningful expressions on invasion and metastasis, two miRNAs (let-7b, miR-210) were highly expressed on angiogenesis, five miRNAs (let-7b, miR-26a, 181d, 181c, 296-5p) related with apoptosis, and six miRNAs (let-7b, miR-200c, 183, 370, 124a, 191) were associated with prognosis of cancer and early diagnostic factors for cancer. Conclusion : The mechanism of miRNA takes a role in diagnosis, treatment, and prognotic factors for cancer as well. This study suggested that further detailed research on overexpression of specific miRNA should be carried out continuously in the future.
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참고문헌 (32)
참고문헌 신청
엄석기 / 2008 / 漢代까지의 종기·혹·덩어리에 對한 疾病認識 考察 / 대한한의학원전학회지 21(2):39~48
Park JH / 2007 / Bridf review about tumor pathology and etiology focusssed on JIJU / Kor J Oriental Oncology 12(1):1~13
Lee SH / 1998 / Literature review on metastasis and growth inhibition of cancer using ‘the activation and the elimination of blood stasis’ / Journal of Haehwa Medicine 7(1):699~710
Professors of Herval medicine in National College of Korean Medicine / 1991 / Herbology / Yonglimsa :439
Yoon SW / 2006 / The study on the Safety and Case Series of the Acute Lymphocytic Leukemia using Rhus Verniciflua Stokes Extract(Nexia) / Kor J Oriental Oncology 11(1):1~21
Park JH / 2007 / Bridf review about tumor pathology and etiology focusssed on JIJU / Kor J Oriental Oncology 12(1):1~13
Lee SH / 1998 / Literature review on metastasis and growth inhibition of cancer using ‘the activation and the elimination of blood stasis’ / Journal of Haehwa Medicine 7(1):699~710
Professors of Herval medicine in National College of Korean Medicine / 1991 / Herbology / Yonglimsa :439
Yoon SW / 2006 / The study on the Safety and Case Series of the Acute Lymphocytic Leukemia using Rhus Verniciflua Stokes Extract(Nexia) / Kor J Oriental Oncology 11(1):1~21
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