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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 382 - 397 (16page)
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Purpose Glioblastoma multiforme (GBM) is the most common adult primary intracranial tumor. The remarkable features of GBM include central necrosis. MicroRNAs (miRNAs) have been considered as diagnostic/prognostic biomarkers for many cancers, including glioblastoma. However, the effect of necrosis on the miRNA expression profile and predicted miRNA-mRNA regulatory information remain unclear. The purpose of this study is to examine the effect of necrotic cells on the modulation of miRNA and mRNA expression profiles and miRNA-mRNA network in CRT-MG cells. Materials and Methods We used human astroglioma cells, CRT-MG, treated with necrotic CRT-MG cells to examine the effect of necrosis on the modulation of miRNA and mRNA by next-generation sequencing. For preparation of necrotic cells, CRT-MG cells were frozen and thawed through cycle of liquid nitrogen–water bath. The putative miRNA-mRNA regulatory relationship was inferred through target information, using miRDB. Results The necrotic cells induced dysregulation of 106 miRNAs and 887 mRNAs. Among them, 11 miRNAs that had a negative correlation value of p < 0.05 by the hypergeometric test were screened, and their target mRNAs were analyzed by Gene Ontology enrichment analysis. Using the Kyoto Encyclopedia of Genes and Genomes database, we also found several necrotic cell treatment-activated pathways that were modulated by relevant gene targets of differentially expressed miRNAs. Conclusion Our result demonstrated that dysregulation of miRNA and mRNA expression profiles occurs when GBM cells are exposed to necrotic cells, suggesting that several miRNAs may have the potential to be used as biomarkers for predicting GBM progression and pathogenesis.
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참고문헌 (62)
참고문헌 신청
Scheithauer BW / 2009 / Development of the WHO classification of tumors of the central nervous system: a historical perspective / Brain Pathol 19:551~564
Nakada M / 2011 / Aberrant signaling pathways in glioma / Cancers (Basel) 3:3242~3278
Hammoud MA / 1996 / Prognostic significance of preoperative MRI scans in glioblastoma multiforme / J Neurooncol 27:65~73
Raza SM / 2002 / Necrosis and glioblastoma: a friend or a foe? A review and a hypothesis / Neurosurgery 51:2~12
Ahn SH / 2016 / Necrotic cells influence migration and invasion of glioblastoma via NF-kappaB/AP-1-mediated IL-8 regulation / Sci Rep 6:24552
Nakada M / 2011 / Aberrant signaling pathways in glioma / Cancers (Basel) 3:3242~3278
Hammoud MA / 1996 / Prognostic significance of preoperative MRI scans in glioblastoma multiforme / J Neurooncol 27:65~73
Raza SM / 2002 / Necrosis and glioblastoma: a friend or a foe? A review and a hypothesis / Neurosurgery 51:2~12
Ahn SH / 2016 / Necrotic cells influence migration and invasion of glioblastoma via NF-kappaB/AP-1-mediated IL-8 regulation / Sci Rep 6:24552
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