MicroRNA and Their Potential Role in Conjunctival Disorders

Nazmul Huda Syed; Embong Zunaina; Shahidan Wan-Nazatul Shima; Malvika Sharma; Ismail Shatriah

doi:10.3341/kjo.2022.0010

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자료유형: 학술저널

저자정보: Nazmul Huda Syed (Universiti Sains Malaysia) Embong Zunaina (Universiti Sains Malaysia) Shahidan Wan-Nazatul Shima (Universiti Sains Malaysia) Malvika Sharma (Universiti Sains Malaysia) Ismail Shatriah (Universiti Sains Malaysia)

저널정보: 대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제36권 제5호

발행연도: 2022.10

수록면: 452 - 462 (11page)

DOI: 10.3341/kjo.2022.0010

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MicroRNAs (miRNAs) are the small noncoding RNA molecules which regulate target gene expression posttranscriptionally.They are known to regulate key cellular processes like inflammation, cell differentiation, cell proliferation, and cell apoptosisacross various ocular diseases. Due to their easier access, recent focus has been laid on the investigation of miRNA expressionand their involvement in several conjunctival diseases. The aim of this narrative review is to provide understanding of themiRNAs and describe the current role of miRNAs as the mediators of the various conjunctival diseases. A literature searchwas made using PubMed, Scopus, and Web of Science databases for studies involving miRNAs in the conjunctival pathologicalconditions. Original articles in the last 10 years involving both human and animal models were included. Literature search retrieved27 studies matching our criteria. Pertaining to the numerous literatures, there is a strong correlation between miRNAand the various pathological conditions that occur in the conjunctiva. miRNAs are involved in various physiological processessuch as cell differentiation, proliferation, apoptosis, development, and inflammation by regulating various signaling pathways,genes, proteins, and mediators. Pterygium was the most studied conjunctival disease for miRNA involvement, whereas miRNAresearch in allergic conjunctivitis is still in its early stages. Our review provides deep insights into the various miRNAs playingan important role in the various conjunctival diseases. miRNAs do have the potential to serve as noninvasive biomarkerswith diagnostic, prognostic, and therapeutic implications. However, multitudinous studies are required to validate miRNAs asthe reliable biomarkers in conjunctival pathologies and its targeted therapy.

#Biomarkers #Conjunctival diseases #MicroRNAs #Small untranslated RNA

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