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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제25권 제2호
- 발행연도
- 2020.1
- 수록면
- 118 - 125 (8page)
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초록· 키워드
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Purpose: Type 1 diabetes (T1D) is an autoimmune disease that involves genetic, epigenetic, and environmental factors. Change in body composition is a potential mechanism for explaining the increased incidence of T1D. Micro RNA-378 (miRNA-378) is a positive regulator of adipogenesis that has yet to be studied in such patients. This study aims to evaluate the miRNA-378 expression profile in peripheral mononuclear cells of T1D patients and controls and to determine its possible association with levels of body fat, interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). Methods: Twenty-four T1D subjects and 20 controls under 18 years of age without autoimmune diseases were studied. miRNA-378 expression profile was determined by TaqMan probes. Body composition was determined by multifrequency bioimpedance. IL-6 and TNF-α serum levels were determined by LUMINEX. Anti-GAD65, anti-IA2, and anti-ZnT8 antibodies were quantified in serum by enzyme immunoassays. Statistical significance was considered P<0.05. Results: Similar body mass index and body fat (kg) were observed between the T1D and control subjects (P=0.55 and P=0.69, respectively). The miRNA-378 expression profile was significantly higher in T1D patients compared with the controls (P<0.05). Lower miRNA-378 expression in prepubertal controls was observed compared to pubertal controls, prepubertal T1D, and pubertal T1D (P<0.05). AntiGAD65, AntilA2, and AntiZnT8 were positively correlated with miRNA-378 (P=0.002, P=0.053, and P=0.007). No statistically significant correlation was observed between miRNA-378 expression and IL-6, TNF-α, or body fat. Conclusion: Elevated miRNA-378 expression in T1D patients compared with controls is linked to pubertal stage but is not associated with proinflammatory status or body composition.
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참고문헌 (40)
참고문헌 신청
Pugliese A / 2013 / The multiple origins of type 1 diabetes / Diabet Med 30:135~146
Nokoff N / 2013 / Pathogenesis of type 1 diabetes : lessons from natural history studies of high-risk individuals / Ann N Y Acad Sci 1281:1~15
Carrasco E / 1996 / One of the lowest validated incidence rates of insulin dependent diabetes mellitus in the Americas: Santiago, Chile / Diabetes Res Clin Pract 34(Suppl):S153~S157
Carrasco E / 2006 / Increasing incidence of type 1 diabetes in population from Santiago of Chile: trends in a period of 18 years (1986-2003) / Diabetes Metab Res Rev 22:34~37
Hewagama A / 2009 / The genetics and epigenetics of autoimmune diseases / J Autoimmun 33:3~11
Nokoff N / 2013 / Pathogenesis of type 1 diabetes : lessons from natural history studies of high-risk individuals / Ann N Y Acad Sci 1281:1~15
Carrasco E / 1996 / One of the lowest validated incidence rates of insulin dependent diabetes mellitus in the Americas: Santiago, Chile / Diabetes Res Clin Pract 34(Suppl):S153~S157
Carrasco E / 2006 / Increasing incidence of type 1 diabetes in population from Santiago of Chile: trends in a period of 18 years (1986-2003) / Diabetes Metab Res Rev 22:34~37
Hewagama A / 2009 / The genetics and epigenetics of autoimmune diseases / J Autoimmun 33:3~11
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