MiR-34b/c rs4938723 Polymorphism Significantly Decreases the Risk of Digestive Tract Cancer: Meta-analysis

Ji, Tian-Xing; Zhi, Cheng; Guo, Xue-Guang; Zhou, Qiang; Wang, Guo-Qiang; Chen, Bo; Ma, Fei-Fei

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자료유형: 학술저널

저자정보: Ji, Tian-Xing (Department of Clinical Laboratory, the Second Affiliated Hospital of Guangzhou Medical University) Zhi, Cheng (Department of Clinical Pathology, the Second Affiliated Hospital of Guangzhou Medical University) Guo, Xue-Guang (Department of Clinical Laboratory, the Third Affiliated Hospital of Guangzhou Medical University) Zhou, Qiang (Department of Clinical Laboratory, the Second Affiliated Hospital of Guangzhou Medical University) Wang, Guo-Qiang (Department of Gastrointestinal Surgery, Lab of Surgery, the Second Affiliated Hospital of Guangzhou Medical University) Chen, Bo (Department of Clinical Laboratory, the Second Affiliated Hospital of Guangzhou Medical University) Ma, Fei-Fei (Department of VIP Obstetrics, the Second Affiliated Hospital of Guangzhou Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제14호

발행연도: 2015.1

수록면: 6,099 - 6,104 (6page)

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Background: Previous studies investigating the association between miR-34b/c rs4938723 polymorphism and cancer risk showed inconclusive. Here, we performed meta-analysis to investigate the association between miR- 34b/c rs4938723 polymorphism and digestive cancer risk. Materials and Methods: Literature database including PubMed, OVID, Chinese National Knowledge Infrastructure (CNKI) were searched for publications concerning the association between the miR-34b/c rs4938723 polymorphism and digestive cancer risk. Results: A total of 6 studies consisting of 3246 cases and 3568 controls were included in this meta-analysis. The combined analysis suggested the miR-34b/c rs4938723 polymorphism significantly reduced digestive cancer risk under allelic model, homogeneous co-dominant model and recessive model (C vs T: OR=0.88, 95%CI=0.82-0.95, p-value=0.001; CC vs TT: OR =0.67, 95%CI=0.57-0.80, p-value=0.000; CC vs TT/TC: OR=0.68, 95%CI=0.58-0.80, p-value=0.000). Q-test and I2 test revealed no significant heterogeneity in all genotype comparisons. The Begger's funnel plot and Egger's test did not show significant publication bias. Conclusions: The current evidence supports the conclusion that the miR-34b/c rs4938723 polymorphism decreases an individual's susceptibility to digestive cancers.

#miR-34b/c #polymorphism #digestive cancer #susceptibility

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Ji, Tian-Xing

소속기관 Department of Clinical Laboratory, the Second Affiliated Hospital of Guangzhou Medical University