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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 446 - 449 (4page)
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Background: High asymmetrical dimethylarginine (ADMA) levels have been associated with endothelial dysfunction and contribute to the development of several diseases. However, data on the relationship between hepatitis B virus (HBV) and ADMA are limited. The aim of our study was to explore the relationship between ADMA and HBV by comparing the ADMA levels in patients with chronic active hepatitis B (CHB), inactive HBV carriers (carriers), and healthy volunteers (controls). Methods: The participants were divided into three groups: 90 patients with CHB, 90 HBV carriers, and 90 controls. Serum ADMA levels were quantified using an ELISA kit (Cusabio, Wuhan, China). The data were analyzed using an ANOVA or the Kruskal-Wallis test as appropriate, with P<0.05 considered significant. Results: Serum ADMA levels were significantly higher in patients with CHB (228.35±91.10 ng/mL) than in HBV carriers (207.80±75.80 ng/mL) and controls (207.61±89.10 ng/mL) (P=0.049). The clinical scores of the patients were positively correlated with ADMA levels. Conclusions: The elevated serum ADMA levels in patients with CHB confirm that HBV plays a role in vasculitis. Further investigation of the mechanisms contributing to the high levels of ADMA in CHB may contribute toward development of new treatment modalities
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참고문헌 (26)
참고문헌 신청
Aldamiz-Echevarria L / 2012 / Asymmetric dimethylarginine, endothelial dysfunction and renal disease / Int J Mol Sci 13:11288~11311
Liu X / 2016 / Effect of asymmetric dimethlarginine (ADMA) on heart failure development / Nitric Oxide 54:73~81
Tain YL / 2017 / Toxic dimethylarginines: asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) / Toxins (Basel) 9:E92
McCarty MF / 2016 / Asymmetric dimethylarginine is a well-established mediating risk factor for cardiovascular morbidity and mortality-should patients with elevated levels be supplemented with citrulline / Healthcare (Basel) 4:E40
Erbil MK / 2012 / Metabolism of asymmetric dimethylarginine and its clinical significance / Turk J Bioch 37:99~105
Liu X / 2016 / Effect of asymmetric dimethlarginine (ADMA) on heart failure development / Nitric Oxide 54:73~81
Tain YL / 2017 / Toxic dimethylarginines: asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) / Toxins (Basel) 9:E92
McCarty MF / 2016 / Asymmetric dimethylarginine is a well-established mediating risk factor for cardiovascular morbidity and mortality-should patients with elevated levels be supplemented with citrulline / Healthcare (Basel) 4:E40
Erbil MK / 2012 / Metabolism of asymmetric dimethylarginine and its clinical significance / Turk J Bioch 37:99~105
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