Role of IL-18 Gene Promoter Polymorphisms, Serum IL-18 Levels, and Risk of Hepatitis B Virus-related Liver Disease in the Guangxi Zhuang Population: a Retrospective Case-Control Study

Lu, Yu; Bao, Jin-Gui; Deng, Yan; Rong, Cheng-Zhi; Liu, Yan-Qiong; Huang, Xiu-Li; Song, Liu-Ying; Li, Shan; Qin, Xue

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자료유형: 학술저널

저자정보: Lu, Yu (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Bao, Jin-Gui (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Deng, Yan (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Rong, Cheng-Zhi (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Liu, Yan-Qiong (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Huang, Xiu-Li (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Song, Liu-Ying (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Li, Shan (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) Qin, Xue (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제14호

발행연도: 2015.1

수록면: 6,019 - 6,026 (8page)

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Background: The aim of this study was to assess the relationship between IL-18 gene polymorphisms and HBV-related diseases and whether these polymorphisms influence its expression in the Guangxi Zhuang population. Materials and Methods: We enrolled 129 chronic HBV infected (CHB) patients, 86 HBV-related liver cirrhosis (LC) patients and 160 healthy controls in our study. Polymerase chain reaction-restriction fragment length polymorphism methods were used to detect IL-18 gene -607C/A, -137G/C polymorphisms, and an ELISA kit was employed to determine serum IL-18 levels. Results: No correlation was found between the -607C/A polymorphism and risk of HBV-related disease. For the -137G/C polymorphism, the GC genotype and C allele were associated with a significantly lower risk of CHB (95%CI: 0.32-0.95, p=0.034 and 95%CI: 0.35-0.91, p=0.018) and HBV-related LC (95%CI: 0.24-0.89, p=0.022 and 95%CI: 0.28-0.90, p=0.021). A similar decreased risk was also found with the A-607C-137 haplotype. With respect to IL-18 expression, it was significantly lower in both patient groups, but no association was noted between the two polymorphisms in the IL-18 gene and its expression. Conclusions: Our study indicated that the -137C allele in the IL-18 gene may be a protective factor for HBV-related disease, and serum IL-18 level may be inversely associated with CHB and HBV-related LC.

#Interleukin-18, polymorphism #expression #chronic hepatitis B #Liver cirrhosis

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