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논문 기본 정보

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저자정보
Çağrı Yayla (Department of Cardiology School of Medicine Gazi University) Kaan Okyay (Department of Cardiology School of Medicine Baskent University) Asife Şahinarslan (Department of Cardiology School of Medicine Gazi University) Akın Yılmaz (Department of Medical Biology and Genetic School of Medicine Gazi University Ankara Turkey) Atiye Seda Yar Sağlam (Department of Medical Biology and Genetic School of Medicine Gazi University Ankara Turkey) Azmi Eyiol (Department of Cardiology School of Medicine Gazi University) Hasan Ata Bolayır (Department of Cardiology School of Medicine Gazi University) Burak Sezenöz (Department of Cardiology School of Medicine Gazi University) Sevda Menevşe (Gazi University) Atiye Çengel (Department of Cardiology School of Medicine Gazi University)
저널정보
대한심장학회 Korean Circulation Journal Korean Circulation Journal Vol.46 No.5
발행연도
2016.1
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615 - 621 (7page)

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Background and Objectives: Genetic predisposition is an important risk factor for coronary artery disease (CAD). In this study, we aimed to evaluate the impact of rs10757274 and rs2383206 polymorphisms in chromosome 9p21 on presence and severity of CAD in a Turkish population. Subjects and Methods: A total of 646 patients who underwent coronary angiography were included in this study. Coronary vessel score and Gensini score were calculated to assess the angiographic severity of CAD. Alleles of AA, AG, and GG were determined for rs10757274 (polymorphism-1) and rs2383206 (polymorphism-2) polymorphisms located in chromosome 9p21 from the blood samples. Results: There was a significant difference between the alleles in polymorphism-1 in the presence of coronary artery disease (38.9% in AA, 48.0% in GG and 56.4% in AG, p=0.017). However, there was no difference between the alleles in polymorphism-2. According to vessel scores, there was a significant difference between the alleles in polymorphism-1 (AA 0.71±1.04, GG 0.88±1.07, AG 1.06±1.12, p=0.018). In polymorphism-2, vessel scores did not show a difference between the alleles. In polymorphism-1, there was a significant difference in Gensini score (p=0.041). Gensini scores did not differ between the alleles in polymorphism-2 (p>0.05 for all). In multivariate analyses, none of the alleles was an independent factor for presence of CAD. Conclusion: The presence of rs10757274 polymorphism including AG allele in chromosome 9p21 was related to CAD. However, this relationship was not independent of other cardiovascular risk factors.

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참고문헌 (30)

참고문헌 신청
Okrainec K / 2004 / Coronary artery disease in the developing world / Am Heart J 148:7~15 google schola 안성균 / 2013 / Genotype- and Phenotype-Directed Personalization of Antiplatelet Treatment in Patients with Non-ST Elevation Acute Coronary Syndromes Undergoing Coronary Stenting / Korean Circulation Journal 43(8):541~549 google schola 신동직 / 2013 / Association between Serine/Threonine Kinase 39 Gene Polymorphism, Hypertension, and Other Cardiovascular Risk Factors in Koreans / Korean Circulation Journal 43(1):13~22 google schola 유상용 / 2012 / Rho-Associated Kinase 2 Polymorphism in Patients With Vasospastic Angina / Korean Circulation Journal 42(6):406~413 google schola Chan L / 1994 / Gene-environment interactions and gene therapy in atherosclerosis / Cardiol Rev 2:130~137 google schola

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