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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 595 - 601 (7page)
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초록· 키워드
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Background: The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management. We investigated the β-lactamases in a group of carbapenem-resistant K. pneumoniae clinical isolates from Turkey.
Methods: Thirty-seven strains of K. pneumoniae isolated from various clinical specimens were analyzed by antimicrobial susceptibility testing, PCR for the detection of β-lactamase genes, DNA sequencing, and repetitive extragenic palindronic (REP)- PCR analysis.
Results: All 37 isolates were resistant to ampicillin, ampicillin/sulbactam, piperacillin, piperacillin/tazobactam, ceftazidime, cefoperazone/sulbactam, cefepime, imipenem, and meropenem. The lowest resistance rates were observed for colistin (2.7%), tigecycline (11%), and amikacin (19%). According to PCR and sequencing results, 98% (36/37) of strains carried at least one carbapenemase gene, with 32 (86%) carrying OXA-48 and 7 (19%) carrying NDM-1. No other carbapenemase genes were identified. All strains carried a CTX-M-2-like β-lactamase, and some carried SHV- (97%), TEM- (9%), and CTX-M-1-like (62%) β-lactamases. Sequence analysis of blaTEM genes identified a blaTEM-166 with an amino acid change at position 53 (Arg53Gly) from blaTEM-1b, the first report of a mutation in this region. REP-PCR analysis revealed that there were seven different clonal groups, and temporo-spatial links were identified within these groups.
Conclusions: Combinations of β-lactamases were found in all strains, with the most common being OXA-48, SHV, TEM, and CTX-M-type (76% of strains). We have reported, for the first time, a high prevalence of the NDM-1 (19%) carbapenemase in carbapenem-resistant K. pneumoniae from Turkey. These enzymes often co-exist with other β-lactamases, such as TEM, SHV, and CTX-M β-lactamases.
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참고문헌 (30)
참고문헌 신청
Seija V / 2015 / Sepsis caused by New Delhi metallo-β-lactamase (blaNDM-1) and qnrD-producing Morganella morganii, treated successfully with fosfomycin and meropenem: case report and literature review / Int J Infect Dis 30:20~26
Nordmann P / 2011 / The emerging NDM carbapenemases / Trends Microbiol 19:588~595
Kim SY / 2014 / Characteristics of community-onset NDM-1-producing Klebsiella pneumonia isolates / J Med Microbiol 63:86~89
Rasheed JK / 2013 / New Delhi metallo-β-lactamase-producing Enterobacteriaceae, United States / Emerg Infect Dis 19:870~878
Evans B / 2014 / OXA β-lactamases / Clin Microbiol Rev 27:241~263
Nordmann P / 2011 / The emerging NDM carbapenemases / Trends Microbiol 19:588~595
Kim SY / 2014 / Characteristics of community-onset NDM-1-producing Klebsiella pneumonia isolates / J Med Microbiol 63:86~89
Rasheed JK / 2013 / New Delhi metallo-β-lactamase-producing Enterobacteriaceae, United States / Emerg Infect Dis 19:870~878
Evans B / 2014 / OXA β-lactamases / Clin Microbiol Rev 27:241~263
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