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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 434 - 440 (7page)
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초록· 키워드
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Background: Rapid detection of carbapenemase-producing gram-negative bacilli (GNB) is required for optimal treatment of infected patients. We developed and assessed a new disk carbapenemase test (DCT).
Methods: Paper disks containing 0.3 mg of imipenem and bromothymol blue indicator were developed, and the performance of the DCT were evaluated by using 742 strains of GNB with or without carbapenemases.
Results: The paper disks were simple to prepare, and the dried disks were stable at -20°C and at 4°C. The DCT detected 212 of 215 strains (98.6% sensitivity with 95% confidence interval [CI] 96.0-99.5%) of GNB with known class A (KPC and Sme) and class B (NDM, IMP, VIM, and SIM) carbapenemases within 60 min, but failed to detect GES-5 carbapenemase. The DCT also detected all two Escherichia coli isolates with OXA-48, but failed to detect GNB with OXA-232, and other OXA carbapenemases. The DCT showed 100% specificity (95% CI, 99.2-100%) in the test of 448 imipenem-nonsusceptible, but carbapenemase genes not tested, clinical isolates of GNB.
Conclusions: The DCT is simple and can be easily performed, even in small laboratories, for the rapid detection of GNB with KPC, NDM and the majority of IMP, VIM, and SIM carbapenemases.
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참고문헌 (16)
참고문헌 신청
Lee K / 2001 / Modified Hodge test and EDTA-disk synergy tests to screen metallo-β-lactamase-producing strains of Pseudomonas and Acinetobacter species / Clin Microbiol Infect 7:88~91
Nordmann P / 2012 / Rapid detection of carbapenemase-producing Enterobacteriaceae / Emerg Infect Dis 18:1503~1507
Dortet L / 2012 / Rapid identification of carbapenemase types in Enterobacteriaceae and Pseudomonas spp. by using a biochemical test / Antimicrob Agents Chemother 56:6437~6440
Clinical and Laboratory Standards Institute / 2015 / Performance standards for antimicrobial susceptibility testing.Twenty-fifth Informational supplement, M100-S25 / Clinical and Laboratory Standards Institute
Pires J / 2013 / Blue-carba, an easy biochemical test for detection of diverse carbapenemase producers directly from bacterial cultures / J Clin Microbiol 51:4281~4283
Nordmann P / 2012 / Rapid detection of carbapenemase-producing Enterobacteriaceae / Emerg Infect Dis 18:1503~1507
Dortet L / 2012 / Rapid identification of carbapenemase types in Enterobacteriaceae and Pseudomonas spp. by using a biochemical test / Antimicrob Agents Chemother 56:6437~6440
Clinical and Laboratory Standards Institute / 2015 / Performance standards for antimicrobial susceptibility testing.Twenty-fifth Informational supplement, M100-S25 / Clinical and Laboratory Standards Institute
Pires J / 2013 / Blue-carba, an easy biochemical test for detection of diverse carbapenemase producers directly from bacterial cultures / J Clin Microbiol 51:4281~4283
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