지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 138 - 144 (7page)
이용수
초록· 키워드
오류제보하기
Background: Extensively drug-resistant (XDR) Pseudomonas aeruginosa and Acinetobacter baumannii are a threat to hospitalized patients. We evaluated the effects of antimicrobial combinations on XDR P. aeruginosa and A. baumannii isolates.
Methods: P. aeruginosa and A. baumannii isolates, which were resistant to all antibiotics except colistin (CL), were collected from eight hospitals in Korea. Genes encoding metallo-β-lactamases (MBLs) and OXA carbapenemases were detected by PCR in eight P. aeruginosa and 30 A. baumannii isolates. In vitro synergy of antimicrobial combinations was tested by using the checkerboard method.
Results: Minimum inhibitory concentrations of β-lactams, aminoglycosides, and fluoroquinolones were very high, while that of CL was low for majority of XDR P. aeruginosa and A. baumannii isolates. Antimicrobial combinations including Imipenem (IPM)-CL, ceftazidime (CAZ)-CL, and rifampin (RIF)-CL exerted only additive/indifferent effects on majority of XDR P. aeruginosa isolates. Proportions of XDR A. baumannii isolates that showed synergistic and additive/indifferent inhibition after treatment with antimicrobial combinations used are as follows: IPM-ampicillin-sulbactam (AMS), 17% and 80% isolates, respectively; IPM-rifampin (RIF), 13% and 81% isolates, respectively; IPM-CL, 13% and 87% isolates, respectively; and RIF-COL, 20% and 73% isolates, respectively. Significant proportion (19%) of XDR P. aeruginosa isolates produced MBLs, and majority (82%) of A. baumannii isolates produced either MBLs or OXA-23.
Conclusions: Our results suggest that combinations of IPM-AMS, IPM-RIF, IPM-CL, and RIF-CL are more useful than individual drugs for treating 13-20% of XDR A. baumannii infections.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Lister PD / 2009 / Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms / Clin Microbiol Rev 22:582~610
Peleg AY / 2008 / Acinetobacter baumannii: emergence of a successful pathogen / Clin Microbiol Rev 21:538~582
이경원 / 2011 / Further Increases in Carbapenem-, Amikacin-, and Fluoroquinolone-Resistant Isolates of Acinetobacter spp. and P. aeruginosa in Korea: KONSAR Study 2009 / Yonsei Medical Journal 52(5):793~802
Huh K / 2013 / Continuous increase of the antimicrobial resistance among gram-negative pathogens causing bacteremia: a nationwide surveillance study by the Korean Network for Study on Infectious Diseases (KONSID) / Diagn Microbiol Infect Dis 76:477~482
Koch-Weser J / 1970 / Adverse effects of sodium colistimethate. Manifestations and specific rates during 317 courses of therapy / Ann Intern Med 72:857~868
Peleg AY / 2008 / Acinetobacter baumannii: emergence of a successful pathogen / Clin Microbiol Rev 21:538~582
이경원 / 2011 / Further Increases in Carbapenem-, Amikacin-, and Fluoroquinolone-Resistant Isolates of Acinetobacter spp. and P. aeruginosa in Korea: KONSAR Study 2009 / Yonsei Medical Journal 52(5):793~802
Huh K / 2013 / Continuous increase of the antimicrobial resistance among gram-negative pathogens causing bacteremia: a nationwide surveillance study by the Korean Network for Study on Infectious Diseases (KONSID) / Diagn Microbiol Infect Dis 76:477~482
Koch-Weser J / 1970 / Adverse effects of sodium colistimethate. Manifestations and specific rates during 317 courses of therapy / Ann Intern Med 72:857~868
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A 5-Year Surveillance Study on Antimicrobial Resistance of Acinetobacter baumannii Clinical Isolates from a Tertiary Greek Hospital
Infection and Chemotherapy
2016 .01
-
In Vitro Interactions of Antibiotic Combinations of Colistin, Tigecycline, and Doripenem Against Extensively Drug-Resistant and Multidrug-Resistant Acinetobacter baumannii
Annals of Laboratory Medicine
2016 .01
-
A Case of Community-Acquired Pneumonia Caused by Multidrug-Resistant Acinetobacter baumannii in Korea
Infection and Chemotherapy
2017 .01
-
Seasonal and Temperature-Associated Increase in Community-Onset Acinetobacter baumannii Complex Colonization or Infection
Annals of Laboratory Medicine
2018 .01
-
Prevalence, Antimicrobial Susceptibility, and Carbapenem Resistance of Non-baumannii Acinetobacter Species in Three Korean Hospitals
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2024 .06
-
Lung Transplantation in a Patient with Pre-transplant Colonization of Extensively Drug-resistant Acinetobacter baumannii
Acute and Critical Care
2015 .01
-
Interleukin-10 is critical for the protection of mice from lethality by lung infection of Acinetobacter baumannii
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Antimicrobial Resistance Patterns of Acinetobacter baumannii and Pseudomonas aeruginosa Isolated From Vulnerable Patients in Korea, 2021
Annals of Clinical Microbiology
2022 .12
-
In Vivo Selection of Pan-Drug Resistant Acinetobacter baumannii during Antibiotic Treatment
Yonsei Medical Journal
2015 .01
-
The Nod2 in essential for host immune defense against Acinetobacter baumannii infection
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Antibiotic Resistance of Acinetobacter baumannii in Iran: A Systemic Review of the Published Literature
Osong Public Health and Research Persptectives
2015 .04
-
Abrupt Increase in Rate of Imipenem Resistance in Acinetobacter baumannii Complex Strains Isolated from General Hospitals in Korea and Correlation With Carbapenem Administration During 2002–2013
Annals of Laboratory Medicine
2018 .01
-
Colistin, Hot Potato for the Therapy of Carbapenem-resistant Acinetobacter baumannii infections
Journal of Korean Medical Science
2019 .01
-
효과적인 자동 미생물 동정기기용 Card Panel 선택을 위한 Acinetobacter baumannii와 유사 그람 음성 세균에 대한 선별검사법 개발
한국보건기초의학회지
2022 .06
-
Evolution of Antimicrobial Resistance Levels of ESKAPE Microorganisms in a Peruvian IV-Level Hospital
Infection and Chemotherapy
2021 .09
-
Clinical and Economic Evaluation of Multidrug-Resistant Acinetobacter baumannii Colonization in the Intensive Care Unit
Infection and Chemotherapy
2016 .01
-
Nucleotide-binding oligomerization domain 1 is dispensable for host immune responses against pulmonary infection of Acinetobacter baumannii in mice
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Characteristics of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa in Korea
Infection and Chemotherapy
2015 .01
-
Antimicrobial Susceptibility and Clonal Distribution of the Blood Isolates of Pseudomonas aeruginosa from Two Korean Hospitals
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .12
-
Development of a Novel Immunochromatographic Assay for Rapid Detection of OXA-23 β-lactamase-producing Acinetobacter baumannii
대한의생명과학회지
2016 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0