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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 491 - 500 (10page)
이용수
초록· 키워드
오류제보하기
Objective: To investigate the functional recovery following the transplantation of human embryonic stem (hES) cells into an injured rat spinal cord. Method: Sprague-Dawley rats were subjected to the spinal cord injury (SCI) using the New York University impactor. The rats were randomly allocated into three groups of 12 rats each, one media-treated and two hES cell-transplanted groups (5×103/5μl, 2×104/5μl). The hES cells were transplanted 1 week after a SCI. Results: The hES cells transplanted into the rats were found to promote the hind limb performance 8 weeks after transplantation. In the electrophysiological study, the transplanted rats showed significantly shortened latencies and increased amplitudes of motor and somatosensory evoked potentials, compared to the media-treated rats. In the spinal cord of the hES cell-treated group, the pathological findings including the glial scar formation and degenerative changes were attenuated and the human Tau protein-positive cells were identified in the vicinity of the necrotic cavity and in the white matter. Conclusion: These results suggest that the transplantation of hES cells might play a role in promoting the functional recovery after a SCI.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Akiyama Y / 2001 / Transplantation of clonal neural precursor cells derived from adult human brain established functional peripheral myelin in the rat spinal cord / Exp Neuro
Amit M / 2000 / Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture / Dev Biol 227 : 271 ~ 278
Bambakidis NC / 2004 / Transplantation of oligodendrocyte precursors and sonic hedgehog results in improved function and white matter sparing in the spinal cords of adult rat
Basso DM / 1995 / A sensitive and reliable locomotor rating scale for open field testing in rats / J Neurotrauma 12 : 1 ~ 21
Bradbury EJ / 2002 / Chondroitinase ABC promotes functional recovery after spinal cord injury / Nature 416 : 636 ~ 640
Amit M / 2000 / Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture / Dev Biol 227 : 271 ~ 278
Bambakidis NC / 2004 / Transplantation of oligodendrocyte precursors and sonic hedgehog results in improved function and white matter sparing in the spinal cords of adult rat
Basso DM / 1995 / A sensitive and reliable locomotor rating scale for open field testing in rats / J Neurotrauma 12 : 1 ~ 21
Bradbury EJ / 2002 / Chondroitinase ABC promotes functional recovery after spinal cord injury / Nature 416 : 636 ~ 640
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