Curcumin Increase the Expression of Neural Stem/Progenitor Cells and Improves Functional Recovery after Spinal Cord Injury

Bang, Woo-Seok; Kim, Kyoung-Tae; Seo, Ye Jin; Cho, Dae-Chul; Sung, Joo-Kyung; Kim, Chi Heon

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자료유형: 학술저널

저자정보: Bang, Woo-Seok (Department of Neurosurgery, Kyungpook National University Hospital) Kim, Kyoung-Tae (Department of Neurosurgery, Kyungpook National University Hospital) Seo, Ye Jin (Department of Neurosurgery, Kyungpook National University Hospital) Cho, Dae-Chul (Department of Neurosurgery, Kyungpook National University Hospital) Sung, Joo-Kyung (Department of Neurosurgery, Kyungpook National University Hospital) Kim, Chi Heon (Department of Neurosurgery, Seoul National University Hospital)

저널정보: 대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제61권 제1호

발행연도: 2018.1

수록면: 10 - 18 (9page)

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Objective : To investigates the effect of curcumin on proliferation of spinal cord neural stem/progenitor cells (SC-NSPCs) and functional outcome in a rat spinal cord injury (SCI) model. Methods : Sixty adult male Sprague-Dawley rats were randomly and blindly allocated into three groups (sham control group; curcumin treated group after SCI; vehicle treated group after SCI). Functional recovery was evaluated by the Basso, Beattie, and Bresnahan (BBB) scale during 6 weeks after SCI. The expression of SC-NSPC proliferation and astrogliosis were analyzed by nestin/Bromodeoxyuridine (BrdU) and Glial fibrillary acidic protein (GFAP) staining. The injured spinal cord was then examined histologically, including quantification of cavitation. Results : The BBB score of the SCI-curcumin group was better than that of SCI-vehicle group up to 14 days (p<0.05). The coimmunoreactivity of nestin/BrdU in the SCI-curcumin group was much higher than that of the SCI-vehicle group 1 week after surgery (p<0.05). The GFAP immunoreactivity of the SCI-curcumin group was remarkably lower than that of the SCI-vehicle group 4 weeks after surgery (p<0.05). The lesion cavity was significantly reduced in the curcumin group as compared to the control group (p<0.05). Conclusion : These results indicate that curcumin could increase the expression of SC-NSPCs, and reduce the activity of reactive astrogliosis and lesion cavity. Consequently curcumin could improve the functional recovery after SCI via SC-NSPC properties.

#Curcumin #Spinal cord injuries #Neural stem progenitor cells #Lesion cavity #Astrogliosis #Functional recovery

참고문헌 (1)

참고문헌 신청

Sihoon Son / 2014 / Curcumin Stimulates Proliferation of Spinal Cord Neural Progenitor Cells via a Mitogen-Activated Protein Kinase Signaling Pathway / 대한신경외과학회지 56(1):1~4

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