Review of the UBC Porcine Model of Traumatic Spinal Cord Injury

Kim, Kyoung-Tae; Streijger, Femke; Manouchehri, Neda; So, Kitty; Shortt, Katelyn; Okon, Elena B.; Tigchelaar, Seth; Cripton, Peter; Kwon, Brian K.

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자료유형: 학술저널

저자정보: Kim, Kyoung-Tae (Department of Neurosurgery, Kyungpook National University Hospital) Streijger, Femke (International Collaboration on Repair Discoveries [ICORD], University of British Columbia) Manouchehri, Neda (International Collaboration on Repair Discoveries [ICORD], University of British Columbia) So, Kitty (International Collaboration on Repair Discoveries [ICORD], University of British Columbia) Shortt, Katelyn (International Collaboration on Repair Discoveries [ICORD], University of British Columbia) Okon, Elena B. (International Collaboration on Repair Discoveries [ICORD], University of British Columbia) Tigchelaar, Seth (International Collaboration on Repair Discoveries [ICORD], University of British Columbia) Cripton, Peter (International Collaboration on Repair Discoveries [ICORD], University of British Columbia) Kwon, Brian K. (International Collaboration on Repair Discoveries [ICORD], University of British Columbia)

저널정보: 대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제61권 제5호

발행연도: 2018.1

수록면: 539 - 547 (9page)

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Traumatic spinal cord injury (SCI) research has recently focused on the use of rat and mouse models for in vivo SCI experiments. Such small rodent SCI models are invaluable for the field, and much has been discovered about the biologic and physiologic aspects of SCI from these models. It has been difficult, however, to reproduce the efficacy of treatments found to produce neurologic benefits in rodent SCI models when these treatments are tested in human clinical trials. A large animal model may have advantages for translational research where anatomical, physiological, or genetic similarities to humans may be more relevant for pre-clinically evaluating novel therapies. Here, we review the work carried out at the University of British Columbia (UBC) on a large animal model of SCI that utilizes Yucatan miniature pigs. The UBC porcine model of SCI may be a useful intermediary in the pre-clinical testing of novel pharmacological treatments, cell-based therapies, and the "bedside back to bench" translation of human clinical observations, which require preclinical testing in an applicable animal model.

#Spinal cord injuries #Porcine model #Translational medical research #Preclinical testing

참고문헌 (29)

참고문헌 신청

방우석 / 2013 / Valproic Acid Increases Expression of Neuronal Stem/Progenitor Cell in Spinal Cord Injury / 대한신경외과학회지 54(1):8~13

Browne KD / 2011 / Mild traumatic brain injury and diffuse axonal injury in swine / J Neurotrauma 28:1747~1755

Donati G / 2008 / Caspaserelated apoptosis in chronic ischaemic microangiopathy following experimental vein occlusion in mini-pigs / Acta Ophthalmol 86:302~306

Jones CF / 2013 / Cerebrospinal fluid pressures resulting from experimental traumatic spinal cord injuries in a pig model / J Biomech Eng 135:101005

Jones CF / 2012 / Development of a large-animal model to measure dynamic cerebrospinal fluid pressure during spinal cord injury: laboratory investigation / J Neurosurg Spine 16:624~635

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Kim, Kyoung-Tae

소속기관 Department of Neurosurgery, Kyungpook National University Hospital

주요연구분야 의약학 > 임상의학 > 신경외과학

논문수 29 이용수 6

Streijger, Femke