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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 320 - 324 (5page)
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초록· 키워드
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Background: We investigated the whole genome sequence (WGS) of a carbapenem-resistant Acinetobacter baumannii isolate belonging to the global clone 2 (GC2) and predicted resistance islands using a software tool.
Methods: A. baumannii strain YU-R612 was isolated from the sputum of a 61-yr-old man with sepsis. The WGS of the YU-R612 strain was obtained by using the PacBio RS II Sequencing System (Pacific Biosciences Inc., USA). Antimicrobial resistance genes and resistance islands were analyzed by using ResFinder and Genomic Island Prediction software (GIPSy), respectively.
Results: The YU-R612 genome consisted of a circular chromosome (ca. 4,075 kb) and two plasmids (ca. 74 kb and 5 kb). Its sequence type (ST) under the Oxford scheme was ST191, consistent with assignment to GC2. ResFinder analysis showed that YU-R612 possessed the following resistance genes: four β-lactamase genes blaADC-30, blaOXA-66, blaOXA-23, and blaTEM-1; armA, aadA1, and aacA4 as aminoglycoside resistance-encoding genes; aac(6’)Ib-cr for fluoroquinolone resistance; msr(E) for macrolide, lincosamide, and streptogramin B resistance; catB8 for phenicol resistance; and sul1 for sulfonamide resistance. By GIPSy analysis, six putative resistant islands (PRIs) were determined on the YU-R612 chromosome. Among them, PRI1 possessed two copies of Tn2009 carrying blaOXA-23, and PRI5 carried two copies of a class I integron carrying sul1 and armA genes.
Conclusions: By prediction of resistance islands in the carbapenem-resistant A. baumannii YU-R612 GC2 strain isolated in Korea, PRIs were detected on the chromosome that possessed Tn2009 and class I integrons. The prediction of resistance islands using software tools was useful for analysis of the WGS.
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참고문헌 (21)
참고문헌 신청
Peleg AY / 2008 / Acinetobacter baumannii: emergence of a successful pathogen / Clin Microbiol Rev 21:538~582
이경원 / 2011 / Multidrug-Resistant Acinetobacter spp.: Increasingly Problematic Nosocomial Pathogens / Yonsei Medical Journal 52(6):879~891
정혜선 / 2014 / Characterization of the Multidrug-Resistant Acinetobacter species Causing a Nosocomial Outbreak at Intensive Care Units in a Korean Teaching Hospital: Suggesting the Correlations with the Clinical and Environmental Samples, Including Respiratory Tract-related Instruments / Annals of Clinical Microbiology 17(2):29~34
Boucher HW / 2009 / Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America / Clin Infect Dis 48:1~12
Karageorgopoulos DE / 2008 / Current control and treatment of multidrug-resistant Acinetobacter baumannii infections / Lancet Infect Dis 8:751~762
이경원 / 2011 / Multidrug-Resistant Acinetobacter spp.: Increasingly Problematic Nosocomial Pathogens / Yonsei Medical Journal 52(6):879~891
정혜선 / 2014 / Characterization of the Multidrug-Resistant Acinetobacter species Causing a Nosocomial Outbreak at Intensive Care Units in a Korean Teaching Hospital: Suggesting the Correlations with the Clinical and Environmental Samples, Including Respiratory Tract-related Instruments / Annals of Clinical Microbiology 17(2):29~34
Boucher HW / 2009 / Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America / Clin Infect Dis 48:1~12
Karageorgopoulos DE / 2008 / Current control and treatment of multidrug-resistant Acinetobacter baumannii infections / Lancet Infect Dis 8:751~762
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