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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제45권 제4호
- 발행연도
- 2015.1
- 수록면
- 145 - 151 (7page)
이용수
초록· 키워드
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Purpose: The aim of this study was to investigate the therapeutic effects of a herbal for¬mula, PerioH-035, containing Angelica sinensis, steamed Rehmannia glutinosa, Angelica dahurica, Cimicifuga heracleifolia, and Zanthoxylum piperitum on the periodontal break¬down in a well-established ligature-induced periodontitis model in rats.
Methods: Sprague-Dawley rats were randomly assigned to 1 of 4 groups: NL (non-liga¬tured), L (ligatured), P1 (ligatured and treated with 1 mg/mL PerioH-035), P100 (ligatured and treated with 100 mg/mL PerioH-035). Periodontitis was induced by placing a ligature around the mandibular first molars. PerioH-035 was topically applied to both sides of the first molar for 2 weeks. The right side of the mandibles was retrieved for micro-computed tomography (CT) and methylene blue staining to analyze alveolar bone loss. The left side of the mandibles was histologically analyzed by TRAP and H&E staining. The MMP-9 mRNA level in gingival tissue was investigated by RT-PCR.
Results: Alveolar bone resorption was significantly reduced in the PerioH-035-treated groups. The number of dense multi-nucleated cells found to be TRAP-positive by staining in the ligatured rats was markedly decreased by PerioH-035 application. In addition, peri¬odontal tissue destruction, especially cementum demineralization, was ameliorated in the P1 and P100 groups. Moreover, gingival tissue from the PerioH-035-treated group showed a decrease in the MMP-9 mRNA level, resulting in recovery of collagen degradation.
Conclusions: These results suggest that PerioH-035 has therapeutic effects on periodonti¬tis, and thus, PerioH-035 shows promise as a treatment for periodontitis.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Aimetti M / 2012 / Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial / J Clin Periodo
Apatzidou DA / 2010 / Nonsurgical mechanical treatment strategies for periodontal disease / Dent Clin North Am 54 : 1 ~ 12
Baker PJ / 1999 / CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice / Infect Immun 67 : 2804 ~ 28
Choi YY / 2014 / Topical application of Kochia scoparia inhibits the development of contact dermatitis in mice / J Ethnopharmacol 154 : 380 ~ 385
Deng GG / 2015 / New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells / Fit
Apatzidou DA / 2010 / Nonsurgical mechanical treatment strategies for periodontal disease / Dent Clin North Am 54 : 1 ~ 12
Baker PJ / 1999 / CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice / Infect Immun 67 : 2804 ~ 28
Choi YY / 2014 / Topical application of Kochia scoparia inhibits the development of contact dermatitis in mice / J Ethnopharmacol 154 : 380 ~ 385
Deng GG / 2015 / New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells / Fit
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