지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제45권 제2호
- 발행연도
- 2015.1
- 수록면
- 76 - 80 (5page)
이용수
초록· 키워드
오류제보하기
Purpose: Methimazole is an anti-thyroid drug that can cause life-threatening neutropenia in rare situations. The aim of this case report is to describe a set of oral complications asso¬ciated with methimazole-induced neutropenia and the healing of the gingiva after proper treatment.
Methods: A 31-year-old female patient hospitalized for systemic symptoms of sore throat and fever and showing extensive gingival necrosis with pain was referred to the Depart¬ment of Periodontics from the Department of Endocrinology. Methimazole-induced neu¬tropenia was diagnosed based on blood test results and her medical history. Methimazole was discontinued and a range of treatments was administered, including the injection of granulocyte colony stimulating factor.
Results: After systemic treatment, the gingiva began to heal as the neutrophil count in¬creased. Approximately one year later, the gingiva had returned to a normal appearance. Twenty-one months after treatment, sequestra of the alveolar bone that had broken through the gingiva were removed. Periodic supportive periodontal treatment has been continued uneventfully.
Conclusions: The oral manifestations of gingival necrosis and ulcerations, in combination with systemic symptoms such as fever and sore throat, are the critical signs presented in the early stages of drug-induced neutropenia. Therefore, dentists need to be aware of these oral complications in order to make an accurate diagnosis and to ensure that prompt medi¬cal intervention is provided.
목차
등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Andersohn F / 2007 / Systematic review : agranulocytosis induced by nonchemotherapy drugs / Ann Intern Med 146 : 657 ~ 665
Chen DF / 2003 / Neutropenic colitis with cecal perforation during antithyroid therapy / J Formos Med Assoc 102 : 644 ~ 646
Chien MN / 1995 / Methimazole-induced agranulocytosis treated with recombinant human granulocyte colony-stimulating factor (rhG-CSF): a case report / Zhonghua Yi Xue Za Zhi
Dai WX / 2002 / Retrospective analysis of 18 cases of antithyroid drug (ATD)-induced agranulocytosis / Endocr J 49 : 29 ~ 33
Espinosa DJ / 2000 / Analytical review of multicenter studies with polycresulene for hemorrhoidal pathologies / Acta Gastroenterol Latinoam 30 : 177 ~ 186
Chen DF / 2003 / Neutropenic colitis with cecal perforation during antithyroid therapy / J Formos Med Assoc 102 : 644 ~ 646
Chien MN / 1995 / Methimazole-induced agranulocytosis treated with recombinant human granulocyte colony-stimulating factor (rhG-CSF): a case report / Zhonghua Yi Xue Za Zhi
Dai WX / 2002 / Retrospective analysis of 18 cases of antithyroid drug (ATD)-induced agranulocytosis / Endocr J 49 : 29 ~ 33
Espinosa DJ / 2000 / Analytical review of multicenter studies with polycresulene for hemorrhoidal pathologies / Acta Gastroenterol Latinoam 30 : 177 ~ 186
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