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자료유형
학술저널
저자정보
정민경 (이화여자대학교 의과대학 내과) 김인제 (이화여자대학교) 이지수 (이화여자대학교)
저널정보
대한류마티스학회 대한류마티스학회지 대한류마티스학회지 제24권 제4호
발행연도
2017.1
수록면
203 - 210 (8page)

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Objective. This study estimated the prevalence and explored possible risk factors associated with neutropenia in hospitalized patients with systemic lupus erythematosus (SLE). Methods. This review included 160 admissions of 85 SLE patients between 2006 and 2013. Neutropenia was defined as absolute neutrophil count (ANC) below 1,500/mm3. The baseline characteristics of the patients were compared between patients who experienced neutropenia and those who did not. Clinical and serological factors related to neutropenia episodes during admission were analyzed. Results. Thirty-five (21.9%) neutropenic episodes were found among the 160 admissions. Most of the neutropenic episodes were mild to moderate. Severe neutropenia of ANC <500/mm3 occurred in 3.1% of the cases. Patients with neutropenia had higher frequencies of ANA (100.0% vs. 86.8%, p=0.042) and anti-double stranded DNA (87.5% vs. 60.4%, p=0.008), and satisfied more SLE classification criteria at the time of diagnosis than those without (5.1 vs. 4.6, p=0.009). Anemia, leukopenia, thrombocytopenia and low complement levels were frequently accompanied with neutropenia. Chronic kidney disease (odds ratio, 11.17; 95% confidence interval, 1.46∼85.27; p=0.020) was associated with neutropenia. Conclusion. This study demonstrates that neutropenia is frequent in hospitalized patients with SLE, and patients with neutropenia have more hematologic and immunologic abnormalities. Renal damage was more frequent among those presenting with neutropenia.

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