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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 442 - 452 (11page)
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Objectives: This study was performed to investigate the anti-lipogenic effect and the mechanism of Jungmanbunso-hwan extract (JMBSH) on a cellular model of non-alcoholic fatty liver disease (NAFLD) caused by palmitate in HepG2 cells.
Methods: The JMBSH was prepared, andHepG2 cells were treated with various concentrations of JMBSH in order to perform an MTT assay. The HepG2 cells were cultivated in palmitate-containing media with or without extract of JMBSH.
The intracellular lipid content in the HepG2 cells was examined. The effects of JMBSH on sterol regulatory element-binding transcription factor-1c (SREBP-1c), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD-1), and AMP-activated protein kinase (AMPK) activation in HepG2 cells were measured.
Results: JMBSH did not reduce HepG2 cell viability under 1,000 μg/mL. JMBSH considerably decreased intracellular lipid accumulation caused by palmitate in HepG2 cells. JMBSH repressed expression of SREBP-1c, which mediates the induction of lipogenic genes (ACC, FAS, and SCD-1). JMBSH also activated AMPK, which plays animportant role in the regulation of hepatic lipid metabolism.
Conclusions: This study suggested that JMBSH relieves hepatic steatosis by repressing SREBP-1c, which mediates the induction of lipogenic genes. The anti-lipogenic effect of JMBSH may also be related to the activation of AMPK. Therefore, JMBSH could potentially be applied to NAFLD treatment after further clinical studies.
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참고문헌 (39)
참고문헌 신청
Sourianarayanane A / 2013 / Management of non-alcoholic fatty liver disease / Minerva Gastroenterol Dietol 59(1):69~87
Masuoka HC / 2013 / Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals / Ann N Y Acad Sci 1281:106~122
Brunt EM / 1999 / Nonalcoholic steatohepatitis:a proposal for grading and staging the histological lesions / Am J Gastroenterol 94(9):2467~2474
Jun DW / 2012 / Influence of dietary intake on non-alcoholic fatty liver disease in Korean :1~188
Beaton MD / 2012 / Current treatment options for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis / Can J Gastroenterol 26(6):353~357
Masuoka HC / 2013 / Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals / Ann N Y Acad Sci 1281:106~122
Brunt EM / 1999 / Nonalcoholic steatohepatitis:a proposal for grading and staging the histological lesions / Am J Gastroenterol 94(9):2467~2474
Jun DW / 2012 / Influence of dietary intake on non-alcoholic fatty liver disease in Korean :1~188
Beaton MD / 2012 / Current treatment options for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis / Can J Gastroenterol 26(6):353~357
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