지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objective: Graves' disease, the most common cause of primary hyperthyroidism, is a thyroid specific autoimmune disorder. When resistance to medication is shown in spite of long term therapy with anti-thyroid drugs, radioactive iodine therapy would be chosen in Western medicine. However, this therapy has often been reported to cause patients have hypothyroidism, thus requiring them to take levothyroxine for the rest of their lives. In this study, we evaluate the clinical efficacy and safety of Ahnjeonbaekho-tang (AJBHT) on patients with Graves’ disease. Methods: We prescribed AJBHT for 3 months to two groups: patients who had been taking antithyroid drugs were administered AJBHT after discontinuing the antithyroid drugs (Com-Tx→Single-Tx), and patients who had not been taking antithyroid drugs were started with AJBHT (Single-Tx) immediately. We evaluated the thyroidal function test (TFT) and visual analogue scale (VAS) for clinical symptoms for 3 months. Results: Serum T3 and fT4 were significantly decreased in both groups and remission rate of thyroidal hormones were significantly improved in the Single-Tx group. The clinical symptoms of palpitation, fatigue, and heat intolerance were significantly improved in both groups. In the safety analysis, all patients were in normal range of liver, renal function blood test and common blood count. Conclusion: From these results, we suggested that AJBHT was effective on TFT and clinical symptoms of Graves’ disease. The study supports that AJBHT may be a useful agent for patients with Graves’ disease who are resistant to antithyroid medication or radioactive iodine therapy, and for patients at first diagnosis.
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등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Cho BY / 1993 / The autoimmune pathology of thyroid disease / The Journal of the Korean Medical Association 36:31~39
Min HG / 1999 / Endocrinology / Korea Medical Book Publishing Company :269~290
Cho BY / 2005 / Clinical Thyroidology / Korea Medical Book Publishing Company :277~335
Cooper DS / 2003 / Antithyroid drugs in the management of patients with Graves' disease: an evidence-based approach to therapeutic controversies / J Clin Endocrinol Metab 88(8):3474~3481
Gung SS / 2004 / Progression of renal diseases and antihypertensive treatment / Korean journal of internal medicine 66(2):108~119
Min HG / 1999 / Endocrinology / Korea Medical Book Publishing Company :269~290
Cho BY / 2005 / Clinical Thyroidology / Korea Medical Book Publishing Company :277~335
Cooper DS / 2003 / Antithyroid drugs in the management of patients with Graves' disease: an evidence-based approach to therapeutic controversies / J Clin Endocrinol Metab 88(8):3474~3481
Gung SS / 2004 / Progression of renal diseases and antihypertensive treatment / Korean journal of internal medicine 66(2):108~119
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