지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 92 - 101 (10page)
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초록· 키워드
오류제보하기
Objectives : This study was done with intend to investigate whether two oriental medical prescriptions, daecheongryong-tang (DCRT) and prescription A (P-A) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells.
Methods : Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of DCRT or P-A to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of DCRT and P-A on contractility of isolated tracheal smooth muscle were investigated.
Results were as follows:
1. DCRT significantly inhibited mucin release from cultured HTSE cells, with significant cytotoxicity.
2. P-A significantly increased mucin release from cultured HTSE cells, with significant cytotoxicity.
3. DCRT inhibited Ach-induced contraction of isolated tracheal smooth muscle.
4. P-A also inhibited Ach-induced contraction of isolated tracheal smooth muscle.
Conclusion: Results suggest that DCRT and P-A have regulating effects on mucin secretion from goblet cells. Further investigation is needed, because of the value in finding novel agents to this purpose, and these oriental medical prescriptions have potential for this role.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
/ / Respiratory tract defense mechanism In textbook of pulmonary disease : 2 ~ 47
/ 1981 / Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma 56 : 345 ~ 53
/ 1981 / Quantitation of radiolabeled mucous glycoproteins secreted by tracheal explants : 301 ~ 6
/ 1982 / Continuous multiplication of rabbit tracheal epithelial cells in a defined hormone-supplemented medium 18 : 800 ~ 12
/ 1985 / Biochemical characterization of mucous glycoproteins synthesized and secreted by hamster tracheal epithelial cells in primary culture : 4021 ~ 7
/ 1981 / Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma 56 : 345 ~ 53
/ 1981 / Quantitation of radiolabeled mucous glycoproteins secreted by tracheal explants : 301 ~ 6
/ 1982 / Continuous multiplication of rabbit tracheal epithelial cells in a defined hormone-supplemented medium 18 : 800 ~ 12
/ 1985 / Biochemical characterization of mucous glycoproteins synthesized and secreted by hamster tracheal epithelial cells in primary culture : 4021 ~ 7
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