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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
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- 1 - 11 (11page)
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Background: Liver-expressed antimicrobial peptide-2 (LEAP-2) is an important component of innate immune system in teleosts. In order to understand isoform-specific involvement and regulation of LEAP-2 genes in mud loach (Misgurnus mizolepis, Cypriniformes), a commercially important food fish, this study was aimed to characterize gene structure and expression characteristics of two paralog LEAP-2 isoforms.
Results: Mud loach LEAP-2 isoforms (LEAP-2A and LEAP-2B) showed conserved features in the core structure of mature peptides characterized by four Cys residues to form two disulfide bonds. The two paralog isoforms represented a tripartite genomic organization, known as a common structure of vertebrate LEAP-2 genes. Bioinformatic analysis predicted various transcription factor binding motifs in the 5′-flanking regions of mud loach LEAP-2 genes with regard to development and immune response. Mud loach LEAP-2A and LEAP-2B isoforms exhibited different tissue expression patterns and were developmentally regulated. Both isoforms are rapidly modulated toward upregulation during bacterial challenge in an isoform and/or tissue-dependent fashion.
Conclusion: Both LEAP-2 isoforms play protective roles not only in embryonic and larval development but also in early immune response to bacterial invasion in mud loach. The regulation pattern of the two isoform genes under basal and stimulated conditions would be isoform-specific, suggestive of a certain degree of functional divergence between isoforms in innate immune system in this species
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참고문헌 (22)
참고문헌 신청
Bao B / 2006 / The catfish liver-expressed antimicrobial peptide 2(LEAP-2)gene is expressed in a wide range of tissues and developmentally regulated / Mol Immunol 43 : 367 ~
Beck F / 2010 / The role of Cdx genes in the gut and in axial development / Biochm Soc Trans 38 : 353 ~ 357
Boweles J / 2000 / Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators / Dev Biol 227 : 239 ~ 255
Broekman DC / 2011 / Cod cathelicidin : isolation of mature peptide, cleavage site characterization and developmental expression / Dev Comp Immunol 35 : 296 ~ 303
Budi EH / 2017 / Transforming growth factor-β receptors and smads : regulatory complexity and functional versatility / Trends Cell Biol 27 : 658 ~ 672
Beck F / 2010 / The role of Cdx genes in the gut and in axial development / Biochm Soc Trans 38 : 353 ~ 357
Boweles J / 2000 / Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators / Dev Biol 227 : 239 ~ 255
Broekman DC / 2011 / Cod cathelicidin : isolation of mature peptide, cleavage site characterization and developmental expression / Dev Comp Immunol 35 : 296 ~ 303
Budi EH / 2017 / Transforming growth factor-β receptors and smads : regulatory complexity and functional versatility / Trends Cell Biol 27 : 658 ~ 672
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