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- 학술저널
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- 2017.1
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Two distinct cDNAs encoding aquaporins (mmAQPs 1a and 3a) were isolated and characterized from mud loach Misgurnus mizolepis. The identified mud loach AQP cDNAs encode for polypeptides of 260 and 302 amino acids.
Topology predictions confirmed six putative membrane-spanning domains connected by five loops and the Nand C-terminal domains being cytoplasmic. The mud loach AQPs 1a and 3a showed broad distribution in multiple tissues including immune-responsive tissues as well as osmoregulatory tissues. Hence, the diversity of AQP distribution and expression possibly indicated its differential functions in the regulation of fluid movement in response to environmental stimuli. The transcription of mmAQP genes was differentially modulated by immune challenges. In particular, the mmAQP3a expression level in the liver was more responsive to immune challenges than that of mmAQP1a. Taken together, fish stimulation or infection resulted in significant modulation of mud loach AQP genes, suggesting potential functional roles of these proteins in piscine pathophysiological process.
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참고문헌 (49)
참고문헌 신청
Krogh A / 2001 / Predicting transmembrane protein topology with a hidden Markov model : application to complete genomes / J Mol Biol 305:567~580
Kubista M / 2006 / The real-time polymerase chain reaction / Mol Asp Med 27:95~125
Kwon SR / 2005 / Generation of Edwardsiella tarda ghosts by bacteriophage PhiX174 lysis gene E / Aquaculture 250:16~21
이상윤 / 2011 / Altered expression of mud loach (Misgurnus mizolepis; Cypriniformes) hepcidin mRNA during experimental challenge with non-pathogenic or pathogenic bacterial species / 한국어병학회지 24(3):279~287
Lehmann GL / 2008 / LPS induces the TNF-α-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis / Am J Physiol Gastrointest Liver Physiol 294:G567~G575
Kubista M / 2006 / The real-time polymerase chain reaction / Mol Asp Med 27:95~125
Kwon SR / 2005 / Generation of Edwardsiella tarda ghosts by bacteriophage PhiX174 lysis gene E / Aquaculture 250:16~21
이상윤 / 2011 / Altered expression of mud loach (Misgurnus mizolepis; Cypriniformes) hepcidin mRNA during experimental challenge with non-pathogenic or pathogenic bacterial species / 한국어병학회지 24(3):279~287
Lehmann GL / 2008 / LPS induces the TNF-α-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis / Am J Physiol Gastrointest Liver Physiol 294:G567~G575
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