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Background: After left atrial appendage (LAA) device closure, peri-device leakage into the LAA persists due to incompleteocclusion. We hypothesized that pre-procedural three-dimensional (3D) geometric analysis of the interatrial septum (IAS) and LAAorifice can predict this leakage. We investigated the predictive parameters of LAA device closure obtained from baseline cardiaccomputerized tomography (CT) using a novel 3D analysis system. Methods: We conducted a retrospective study of 22 patients who underwent LAA device closure. We defined peri-device leakageas the presence of a Doppler signal inside the LAA after device deployment (group 2, n = 5) compared with patients withoutperi-device leakage (group 1, n = 17). Conventional parameters were measured by cardiac CT. Angles θ and φ were defined betweenthe IAS plane and the line, linking the LAA orifice center and foramen ovale. Results: Group 2 exhibited significantly better left atrial (LA) function than group 1 (p = 0.031). Pre-procedural θ was alsolarger in this group (41.9° vs. 52.3°, p = 0.019). The LAA cauliflower-type morphology was more common in group 2. Overall,the patients’ LA reserve significantly decreased after the procedure (21.7 mm3 vs. 17.8 mm3, p = 0.035). However, we observed nosignificant interval changes in pre- and post-procedural values of θ and φ in either group (all p > 0.05). Conclusion: Angles between the IAS and LAA orifice might be a novel anatomical parameter for predicting peri-device leakageafter LAA device closure. In addition, 3D CT analysis of the LA and LAA orifice could be used to identify clinically favorable candidatesfor LAA device closure.

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