편평세포암종에서 Cryoablation 후의 면역학적 반응에 대한 연구

유찬기; 장철; 최지연; 홍재형; 김홍종; 조승현; 정광윤; 권순영

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자료유형: 학술저널

저자정보: 유찬기 장철 최지연 홍재형 김홍종 조승현 정광윤 권순영

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제1호

발행연도: 2008.1

수록면: 64 - 69 (6page)

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Cryoablation has been recognized as a potential tool in the treatment of cancer. Beside its ability to cause local destruction of the primary tumor, cryoablation has been claimed to induce a systemic anti-tumor immune response. We compared cryoimmunologic responses between cryoablation and surgical excision in a murine model of squamous cell carcinoma (SCC). Materials and Method：Six-to 8-weeks-old female mice (total n=30) were used for this study. Tumors were established at the flank of C3H mice with the SCCVII cell line, which is an immunogenic murine SCC of spontaneous origin in the C3H/HeJ mice. The mice underwent surgical excision or cryoablation, when the tumors were between 0.3 and 0.6 cm in the largest dimension. Successfully treated mice were re-challenged with the murine bladder cancer cells, namely, SCCVII cell line or MBT-2 cells at the contralateral flank. One week later, secondary tumor growth was estimated. Spleens were harvested from the mice that had no tumor after re-challenge. Effector splenocytes were added to the target SCCVII cells prelabeled with 3H thymidine. Cytotoxicity was investigated by measuring 3H thymidine releases from target cells. Results：After re-challenging the SCCVII cell line, tumors were developed in 33% (1/3) of the mice treated by surgical excision, compared to 0% (0/4) of mice treated by cryoablation. In the cytotoxicity assay, there were no significant differences between the excision and cryoablation group. Conclusion：These results suggest that the anti-tumor immunologic effect of cryoablation in the murine SCC model is not better than that of surgical excision. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:64-9)

#Squamous cell carcinoma·Cryoablation·Immunologic response·Cytotoxicity.

참고문헌 (20)

참고문헌 신청

Airoldi M / 1982 / Specific immunologic stimulation induced by cryosurgery of spinocellular tumors & of the oral cavity / Boll Soc Ital Biol Sper 58 (18) : 1213 ~ 1219

Airoldi M / 1985 / Carcinoma of the tongue and floor of the mouth. Preliminary results of a multidisciplinary approach / J Maxillofac Surg 13 (3) : 111 ~ 115

Bonney WW / 1982 / Loening SA, Narayana AS, et al. Cryosurgery in prostatic cancer / Survival. Urology 19 (1) : 37 ~ 42

Fazio M / 1982 / Secondary immunological response to cryosurgery in various stages of oral cavity neoplasms / Boll Soc Ital Biol Sper 58 (7) : 419 ~ 424

Fazio M / 1984 / Specific immunological stimulation induced by cryosurgery in patients with squamous- cell carcinoma of the oral cavity / J Maxillofac Surg 12 (4) : 153 ~ 15

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