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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제1호
발행연도
2007.1
수록면
43 - 47 (5page)

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Backgroud and Objectives:Human neutrophil elastase (HNE), secreted from neutrophil, is known to cause mucus hyper-secretion in case of airway inflammation. The purpose of this study is to find out about the efect of HNE on the secretion of nasal mucosa. Subjects and Method:For in vitro study, inferior turbinate mucosa samples were obtained from patients who (100 to 400 ng/ml). Concentration of mucin in the culture media was measured by enzyme linked lectin assay (ELLA). In in vivo study, lavage fluid was obtained from patients with chronic rhinosinusits (n= 11) and from the patients with septal deviation as control (n= 10) to measure the concentration of mucin and HNE by ELLA and ELISA, respectively. Results:The concentrations of HNE and patients with chronic rhinosinusits than in that obtained from control (HNE;26.6± 14.6:9.7± 5.5 μg/ml, p= 0.01. Mucin;56.5± 9.3:29.1± 15.5 ng/ml, p= 0.0002). The correlation coefficient betwen the concentration of HNE and mucin was not statistically significant (r= 0.423). The concentration of mucin increased in dose-dependent fashion by increasing the concentration of HNE in in vitro study and HNE (400 ng/ml) significantly increased the concentration of mucin compared with that of control. Conclusion:From this study, we sugest that increased HNE in the inflammation of nasal cavity could have important role in mucus hypersecrtion. (Korean J Otolaryngol 2007 ;50 :43-7)

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