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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제2호
- 발행연도
- 2016.1
- 수록면
- 104 - 108 (5page)
이용수
초록· 키워드
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Objectives. The role of pro-inflammatory cytokines in the course of chronic otitis media with effusion (COME) has been documented. However, there are fewer studies on the action of anti-inflammatory cytokines in the middle ear. We sought determine whether there is an association between COME and anti-inflammatory cytokines and whether there are any differences in the cytokine profile in COME children with and without atopy.
Methods. Eighty-four children were divided into 3 groups: 32 nonatopic children with COME (group NA), 31 atopic children with COME (group A), and 21 children without COME and without atopy (control group C). Specimens from the middle ear were collected and evaluated by enzyme-linked immunosorbent assay for the cytokines interleukin-1 receptor antagonist (IL-1Ra) and immunoregulatory IL-10.
Results. Significantly higher IL-10 concentrations were found in both nonatopic and atopic children with COME compared to controls. No significant differences in IL-1Ra levels were found between atopic and nonatopic children with COME and the control group.
Conclusion. We found no differences in the levels of IL-1Ra in atopic and nonatopic children with COME compared to controls. However, we found elevated IL-10 levels in the middle ear effusions from children with COME, with or without atopy. These elevated immunoregulatory cytokine levels suggest a role for new immunomodulatory treatments to prevent disease progression in COME, regardless of atopy.
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참고문헌 (30)
참고문헌 신청
Skotnicka B. / 2000 / Cytokines in children with otitis media with effusion / Eur Arch Otorhinolaryngol 257(6):323~326
Skotnicka B. / 2008 / Proinflammatory and immunoregulatory cytokines in the middle ear effusions / Int J Pediatr Otorhinolaryngol 72(1):13~17
Matkovic S. / 2007 / Cytokine levels in groups of patients with different duration of chronic secretory otitis / Eur Arch Otorhinolaryngol 264(11):1283~1287
Garlanda C. / 2013 / The interleukin-1 family : back to the future / Immunity 39(6):1003~1018
Aksentijevich I. / 2009 / An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist / N Engl J Med 360(23):2426~2437
Skotnicka B. / 2008 / Proinflammatory and immunoregulatory cytokines in the middle ear effusions / Int J Pediatr Otorhinolaryngol 72(1):13~17
Matkovic S. / 2007 / Cytokine levels in groups of patients with different duration of chronic secretory otitis / Eur Arch Otorhinolaryngol 264(11):1283~1287
Garlanda C. / 2013 / The interleukin-1 family : back to the future / Immunity 39(6):1003~1018
Aksentijevich I. / 2009 / An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist / N Engl J Med 360(23):2426~2437
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