후두 점막의 염증성 질환, 형성이상과 암종에서Cyclin D1 단백의 검출

배창훈; 최영호; 천승민; 김용대; 심영란; 송시연

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자료유형: 학술저널

저자정보: 배창훈 최영호 천승민 김용대 심영란 송시연

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제4호

발행연도: 2006.1

수록면: 415 - 419 (5page)

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Background and Objectives：Cyclin D1 is one of the proteins regulating G1-S transition in the cell cycle and is considered to play an important role in subsequent mitotic division. So it is a candidate of a proto-oncogene implicated in the pathogenesis of several human tumor types, including laryngeal squamous cell carcinomas. The purpose of this study was to investigate the development of tumorigenesis and clinicopathologic means of cyclin D1 protein in squamous cell carcinoma of the larynx. Subjects and Method：Sixty two patients, who have been treated with benign lesion (keratosis and chronic inflammation), dysplasia or squamous cell carcinoma of the larynx from March 1994 to December 1996 were investigated for this purpose. cyclin D1 protein was detected by immunohistochemical technique in the paraffin embedded tissues. Results：The expression of cyclin D1 protein was detected in 6 out of 11 cases (54.5%) in benign lesion, 3 out of 5 cases (60.0%) in mild to moderate dysplasia, 12 out of 18 cases (66.7%) in severe dysplasia and carcinoma in situ, and 36 out of 44 cases (81.8%) in invasive squamous cell carcinoma of the larynx. Of these, the expression of cyclin D1 protein in invasive squamous cell carcinoma was the highest positive rate, and there was significant difference (p<0.05). However, the expression of cyclin D1 protein was not correlated with degree of differentiation, anatomical site, T-stage and N-stage in invasive squamous cell carcinoma of the larynx (p>0.05). Conclusion：Cyclin D1 protein may be considered to play an important role in the development of the tumorigenesis in invasive squamous cell carcinoma of the larynx. (Korean J Otolaryngol 2006;49:415-9)

#후두·편평세포암종·Cylin D1. #Larynx·Squamous cell carcinoma·Cyclin D1.

참고문헌 (20)

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/ 1983 / Cyclin:Aprotein specified by maternal mRNA in sea urchin eggs that is destroyedat each cleavage division 33 : 389 ~ 96

/ 1992 / Amplification of genes within the chromosome11q13 region is indicative of poor prognosis in patients with operablebreast cancer 52 : 5229 ~ 34

/ 1994 / Cyclin D1 transgene impedes lymphocyte maturation and collaboratesin lymphomagenesis with the myc gene 13 : 2124 ~ 30

/ 1994 / Oncogenicactivity of cyclin D1 revealed through cooperation with Ha-ras:Linkbetween cell cycle control and malignant transformation 9 : 323 ~ 6

/ 1995 / D-type cyclins 20 : 187 ~ 190

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소속기관 영남대학교 의과대학 이비인후-두경부외과학교실

주요연구분야 의약학 > 의학 일반 의약학 > 임상의학 > 이비인후과학

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