후두편평세포암에서 Vascular Endothelial GrowthFactor(VEGF)와 Survivin의 발현

김효진; 김기현; 장영도; 조성호; 고윤우; 김동욱; 이병돈; 장혁순

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자료유형: 학술저널

저자정보: 김효진 김기현 장영도 조성호 고윤우 김동욱 이병돈 장혁순

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제12호

발행연도: 2006.1

수록면: 1,188 - 1,193 (6page)

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Background and Objectives：Angiogenesis and alteration of apoptosis are hypothesized to be the mechanisms of the growthof tumor. Vascular endothelial growth factor (VEGF) is considered to be the most primary factor prompting the angiogenesis intumor tissue, which also holds the central position in the course of formation and metastasis of tumor and regulates expression ofsurvivin. The survivin protein is the member of inhibitor of apoptosis protein (IAP) family which inhibits apoptosis. Recently,several authors reported survivin and VEGF expression was found in various cancer tissue and they are suggest to play on theimportant role in cancer development. The purpose of this study is to evaluate the expression of VEGF and survivin and toinvestigate their correlation with the clinical stage, nodal involvement, and histologic grade in the squamous cell carcinoma oflarynx. Subjects and Method：Immunohistochemical staining for the paraffin sections by using a polyclonal antibody forVEGF and survivin by the standard avidin-biotin-peroxidase technique was performed in 19 cases with the squamouse cellcarcinoma of larynx. The relationships between the expression of VEGF and survivin and clinicopathological characteristicswere analyzed. Results：Immunohistochemical analysis showed the expression of VEGF in 15 of 19 cases (78.9%) and survivinin 19 of 19 cases (100%). There was no correlation between the expression of VEGF and survivin and the clinical stage, nodalinvolvement, and histologic grade in the squamous cell carcinoma of larynx (p>0.05). But VEGF results in an increased expressionof survivin (p<0.05). Conclusion：Further study will be needed to understand the relationships between the VEGFand survivin and squamous cell carcinoma of larynx. (Korean J Otolaryngol 2006;49:1188-93)

#후두암·Survivin·VEGF. #Laryngeal neoplasms·Survivin·VEGF.

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참고문헌 신청

/ / Inhibitionof apoptosis by survivin predicts shorter survival rates in colorectalcancer : 5071 ~ 4

/ / What is the evidence that tumors are angiogenesis-dependent : 4 ~ 6

/ 1991 / The molecular basis of cell death : 5 ~ 15

/ 1995 / Mechanism and genes of cellular suicide 267 : 1445 ~ 1449

/ 1995 / Vascular permeabilityfactor/vascular endothelial growth factor, microvascular hyperpermeabilityand angiogenesis 146 (5) : 1029 ~ 1039

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