갑상선유두상암 환자에서 말초혈액의 종양표지자와  임상 소견과의 상관관계

오세준; 이영옥; 이병주; 이진춘; 왕수건; 김용기; 김인주; 손석만

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자료유형: 학술저널

저자정보: 오세준 이영옥 이병주 이진춘 왕수건 김용기 김인주 손석만

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제9호

발행연도: 2008.1

수록면: 812 - 818 (7page)

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Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), hepatocyte growth factor (HGF) and epidermal growth factor (EGF) are involved in the pathogenesis and development of thyroid cancer. The purpose of this study was to find the correlation between serum VEGF, VEGF-C, MMP-9, EGF, HGF and clinicopathologic factors. Subjects and Method：Using enzyme linked immunosorbent assay (ELISA) kit, 64 patients with thyroid papillary cancer, 15 benign thyroid mass patients and 14 healthy normal control were analyzed to investigate the expression of human VEGF, VEGF-C, MMP-9, EGF and HGF. Results：There were no significant differences in the serum levels of VEGF, VEGFC, MMP-9, TGF, EGF between papillary thyroid cancer group and the benign thyroid tumor group. Levels of VEGF and MMP- 9 appeared higher in lateral cervical lymph node metastasis than N0 lymph node metastasis or only cervical component lymph node metastasis. But, the serum VEGF-C level was significantly related with tumor size, T stage, extrathyroidal extension and lateral cervical lymph node metastasis (p=0.043). Conclusion : VEGF, VEGF-C, MMP-9, HGF and EGF could not be used as a diagnostic tool for differentiating malignancy from benign thyroid disease. Serum VEGF, VEGF-C and MMP-9 levels were correlated with lateral cervical lymph node metastasis of papillary thyroid cancer. Consequently, this results suggests that they may serve as preoperative supplementary marker for determining the extent of papillary thyroid cancer surgery. Also, serum VEGF-C levels were correlated with some prognostic factors of papillary thyroid cancer. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:812-8)

#Papillary thyroid cancer·VEGF·VEGF-C·MMP-9·HGF·EGF.

참고문헌 (19)

참고문헌 신청

Bunone G / 1999 / Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features / Am J Pathol 155 (6) : 1

DeGroot LJ / 1990 / Nature history, treatment, and course of papillary thyroid carcinoma / J Clin Endocrinol Metab 71 (2) : 414 ~ 424

Eccles N / 1996 / Mitogenic stimulation of normal and oncogene-transformed human thyroid epithelial cells by hepatocyte growth factor / Mol Cell Endocrinol 117 (2) : 247 ~ 2

Ferrara N / 2004 / Vascular endothelial growth factor: Basic science and clinical progress / Endocr Rev 25 (4) : 581 ~ 611

Hanahan D / 1996 / Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis / Cell 86 (3) : 353 ~ 364

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오세준

소속기관 Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University Hospital, Pusan National University College of Medicine, Busan, Ko