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PURPOSE: The purpose of this study is to examine on the effects of 12 weeks combined exercised on physical fitness, Irisin and BNDF in white-collar women workers who are sedentary lifestyles. METHODS: In this study, there were controlled groups and exercise group: one was composed of women who had no regular exercise program and sedentary lifestyle (n=20), the other was made of white-collar women who had combined exercise, no muscular skeletal disease, same lifestyle (n=19), totally 39 women were participated in this study. Combined exercises were composed of aerobic exercise, resistance exercise, flexibility, and balance exercise: Conducting mid-level exercise with 65% VO2max consumption, 3 times a week, and 80 minutes for 12 weeks. For certifying the purpose of this study, calculate the average and standard deviation of every variant using descriptive statistics and apply analysis of covariance measures ANCOVA for interaction between groups . RESULTS: In LBM and Body fat percentage, there was no significant difference after exercise. In other words, there was significant difference in body fat (p<.001). Physical fitness has some significant difference in muscular strength, muscular endurance, power, balance and flexibility (p<.001; p<.001; p<.05; p<.05; p<.001). but there was no significant difference in VO2max. There was no significant difference in BDNF and Irisin for groups after exercise. CONCLUSIONS: Consequently, it shows that 12 weeks combined exercise made a positive effect on body composition, physical fitness in white-collar woman workers.

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