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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 155 - 163 (9page)
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Bilirubin has an anti-inflammatory effect as an endogenous antioxidant and has been reported to be inversely correlated with hypertension, diabetes, metabolic syndrome, and insulin resistance. On the other hand, there is a lack of research evaluating the association between bilirubin and metabolic syndrome compared to liver-specific indicators. This study examined the association between the total bilirubin and metabolic syndrome prevalence in Korean adults who underwent health screening compared to ALT and GGT. This cross sectional study included 22,568 adult males and females aged 20 years or older who underwent a health examination at the General Hospital of Gyeonggi Province from March 2015 to February 2018. Metabolic syndrome was diagnosed based on the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) guidelines. In both genders, the metabolic syndrome diagnosed group had higher liver enzymes, and the total bilirubin and direct bilirubin were lower than those without the metabolic syndrome risk factors. The serum total bilirubin showed a weak inverse correlation with abdominal obesity (r= −0.066 vs r=−0.055) and triglyceride (r=−0.127 vs r=−0.136) in both males and females, which is weaker than ALT and GGT The data were statistically significant. In addition, total bilirubin as well as ALT and GGT in both men and women were not predictors of the likelihood of developing metabolic syndrome.
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참고문헌 (21)
참고문헌 신청
Roberts CK / 2009 / Oxidative stress and metabolic syndrome / Life Sci 84:705~712
Schwertner HA / 2008 / Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin / Atherosclerosis 198:1~11
Erdogan D / 2006 / Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women / Atherosclerosis 184:431~437
Perlstein TS / 2008 / Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004 / Arterioscler Thromb Vasc Biol 28:166~172
Perlstein TS / 2008 / Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999-2004 / Am J Med 121:781~788
Schwertner HA / 2008 / Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin / Atherosclerosis 198:1~11
Erdogan D / 2006 / Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women / Atherosclerosis 184:431~437
Perlstein TS / 2008 / Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004 / Arterioscler Thromb Vasc Biol 28:166~172
Perlstein TS / 2008 / Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999-2004 / Am J Med 121:781~788
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