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학술저널
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대한고혈압학회 Clinical Hypertension Clinical Hypertension 제21권 제4호
발행연도
2015.1
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1 - 8 (8page)

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Abstract Background Arterial stiffness of patients with coronary artery disease (CAD), which is expected to be increased due to a generalized atherosclerotic process of human body, may be more evident after the acute increase of blood pressure (BP) or peripheral vascular resistance. Isometric handgrip exercise is a simple and easily applicable method to achieve this goal. We investigated the changes of hemodynamic parameters and arterial stiffness indexes after handgrip exercise in patients with CAD. Methods Forty-two subjects, who underwent coronary angiography (CAG), were enrolled. After CAG, baseline arterial waveforms were traced at the aortic root and external iliac artery using right coronary catheters. Arterial waveforms were recorded at 1, 2, and 3 min in the aortic root and at 3 min in the external iliac artery after isometric handgrip exercise at 30% ~ 40% of the maximal handgrip power. Augmentation pressure (AP) and augmentation index (AIx) were measured at aortic pressure waveforms. Pulse wave velocity (PWV) was calculated using the ECG-gated time difference of the upstroke of arterial waveforms and the distance between the aortic root and the external iliac artery. Results Thirty patients had CAD (CAD group), and others showed no significant coronary stenosis (non-CAD group). Baseline hemodynamic parameters including AIx and PWV were not different between both groups. After isometric handgrip exercise, central systolic blood pressure (BP), central diastolic BP, central pulse pressure, peripheral systolic BP, and peripheral pulse pressure were increased in all patients. AIx inclined significantly from 1 min after exercise only in patients with CAD (before 17.7% ± 9.7% vs. 3 min after exercise 22.3% ± 10.7%, p < 0.001). PWV also increased significantly after exercise only in patients with CAD (before 10.03 ± 1.99 m/s vs. 3 min after 11.09 ± 2.45 m/s, p < 0.001). Conclusions Arterial stiffness indexes at rest were not different between patients with and without CAD. After isometric handgrip exercise, increased arterial stiffness became evident only in patients with CAD.
#Arterial stiffness #Aortic pressure #Pulse wave velocity #Coronary artery disease #Isometric exercise

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참고문헌 신청
Bilinska M. / 2010 / Influence of dynamic training on hemodynamic, neurohormonal responses to static exercise and on inflammatory markers in patients after coronary artery bypass grafting / Circ J 74:2598~2604 google schola Geleris P. / 2004 / Effect of cold, isometric exercise, and combination of both on aortic pulse in healthy subjects / Am J Cardiol 93:265~267 google schola Lydakis C. / 2008 / Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise / J Hum Hypertens 22:320~328 google schola Bechlioulis A. / 2013 / Increased aortic pulse wave velocity is associated with the presence of angiographic coronary artery disease in overweight and obese patients / Am J google schola Ben-Shlomo Y. / 2014 / Aortic pulse wave velocity improves cardiovascular event prediction : an individual participant meta-analysis of prospective observational data from 17 google schola

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