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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제60권 제7호
발행연도
2019.1
수록면
619 - 625 (7page)

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Purpose: To evaluate predictors of severe or moderate coronary artery disease (CAD) in individuals with zero or very low (<10)coronary artery calcium (CAC) scores. Materials and Methods: The 1175 asymptomatic persons with zero or very low (<10) CAC scores were analyzed for CAD stenosisusing coronary computed tomography angiography. Moderate and severe CADs were defined as having more than 50% andmore than 70% stenosis in any of the major coronary arteries, respectively. Age, gender, body mass index, hypertension, type IIdiabetes, dyslipidemia, lipid profile, creatinine, and smoking status were evaluated as predictors for moderate and severe CAD. Results: In the study population, moderate and severe CADs were found in 7.5% and 3.3%, respectively. Among evaluated riskfactors, age [odds ratio (OR) 1.04, 95% confidence interval (CI) 1.02–1.07, p<0.001], current smoking status (OR 3.12, 95% CI 1.82–5.34, p<0.001), and CAC 1–9 (OR 1.80, 95% CI 1.08–3.00, p=0.024) were significantly associated with moderate CAD. Meanwhile,age (OR 1.05, 95% CI 1.02–1.08, p=0.003), low high density lipoprotein (HDL) (OR 0.96, 95% CI 0.93–0.99, p=0.003), and currentsmoking status (OR 2.34, 95% CI 1.14–5.30, p=0.022) were found to be significantly associated with severe CAD. Improvement ofdiscrimination power for predicting severe CAD was observed when smoking and HDL cholesterol were serially added into theage model. Conclusion: Smoking showed significant correlations with moderate or severe CAD, and low HDL cholesterol also proved to be apredictor of severe CAD in asymptomatic individuals with extremely low CAC scores.

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