지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 151 - 157 (7page)
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초록· 키워드
오류제보하기
Purpose: To investigate the inhibitory effect and possible mechanism of intraurethral stimulation on overactive bladder (OAB) induced by acetic acid irritation.
Methods: Cystometry was performed in 13 urethane-anesthetized female rats. Intravesical infusion of 0.5% acetic acid was used to irritate the bladder and induce OAB. Multiple cystometrograms were performed with mirabegron, continuous stimulation, mirabegron plus continuous stimulation, and β3-adrenoceptor antagonist plus continuous stimulation to determine the mechanism underlying the inhibitory effect by intraurethral stimulation.
Results: Infusion of acetic acid significantly decreased bladder capacity. Intraurethral stimulation at 2.5 Hz plus mirabegron significantly increased bladder capacity and decreased the nonvoiding contraction count. The changes were strongly inhibited after the β3-adrenoceptor antagonist was administered.
Conclusions: Activation of urethral afferent nerves can reverse OAB, which activates C-fiber afferent nerves. This animal study indicates that intraurethral stimulation may interfere with OAB through hypogastric nerve activation and pudendal nerve neuromodulation.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Andersson KE / 2004 / Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence / Pharmacol Rev 56 : 581 ~ 631
Boggs JW / 2006 / Frequency-dependent selection of reflexes by pudendal afferents in the cat / J Physiol 577 (Pt 1) : 115 ~ 126
Bosch JL / 2000 / Sacral nerve neuromodulation in the treatment of patients with refractory motor urge incontinence: long-term results of a prospective longitudinal study / U
Brazzelli M / 2006 / Efficacy and safety of sacral nerve stimulation for urinary urge incontinence: a systematic review / J Urol 175 (3 Pt 1) : 835 ~ 841
Chen SC / 2012 / Bilateral pudendal afferent stimulation improves bladder emptying in rats with urinary retention / BJU Int 109 : 1051 ~ 1058
Boggs JW / 2006 / Frequency-dependent selection of reflexes by pudendal afferents in the cat / J Physiol 577 (Pt 1) : 115 ~ 126
Bosch JL / 2000 / Sacral nerve neuromodulation in the treatment of patients with refractory motor urge incontinence: long-term results of a prospective longitudinal study / U
Brazzelli M / 2006 / Efficacy and safety of sacral nerve stimulation for urinary urge incontinence: a systematic review / J Urol 175 (3 Pt 1) : 835 ~ 841
Chen SC / 2012 / Bilateral pudendal afferent stimulation improves bladder emptying in rats with urinary retention / BJU Int 109 : 1051 ~ 1058
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