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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 252 - 259 (8page)
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Purpose: Naftopidil ((±)-1-[4-(2-methoxyphenyl) piperazinyl]-3-(1-naphthyloxy) propan-2-ol) is prescribed in several Asian countries for lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Previous animal experiments showed that intrathecal injection of naftopidil abolished rhythmic bladder contraction in vivo. Naftopidil facilitated spontaneous inhibitory postsynaptic currents in substantia gelatinosa (SG) neurons in spinal cord slices. These results suggest that naftopidil may suppress the micturition reflex at the spinal cord level. However, the effect of naftopidil on evoked excitatory postsynaptic currents (EPSCs) in SG neurons remains to be elucidated. Methods: Male Sprague-Dawley rats at 6 to 8 weeks old were used. Whole-cell patch-clamp recordings were made using SG neurons in spinal cord slices isolated from adult rats. Evoked EPSCs were analyzed in Aδ or C fibers. Naftopidil or prazosin, an α1-adrenoceptor blocker, was perfused at 100 μM or 10 μM, respectively. Results: Bath-applied 100 μM naftopidil significantly decreased the peak amplitudes of Aδ and C fiber-evoked EPSCs to 72.0%±7.1% (n=15) and 70.0%±5.5% (n=20), respectively, in a reversible and reproducible manner. Bath application of 10μM prazosin did not inhibit Aδ or C fiber-evoked EPSCs. Conclusions: The present study suggests that a high concentration of naftopidil reduces the amplitude of evoked EPSCs via a mechanism that apparently does not involve α1-adrenoceptors. Inhibition of evoked EPSCs may also contribute to suppression of the micturition reflex, together with nociceptive stimulation.
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참고문헌 (34)
참고문헌 신청
Agarwal A / 2014 / What is the most bothersome lower urinary tract symptom? Individual- and population-level perspectives for both men and women / Eur Urol 65:1211~1217
Abrams P / 2002 / The standardisation of terminology of lower urinary tract function:report from the Standardisation Sub-committee of the International Continence Society / Neurourol Urodyn 21:167~178
Caine M / 1990 / Alpha-adrenergic blockers for the treatment of benign prostatic hyperplasia / Urol Clin North Am 17:641~649
Majima T / 2017 / Effect of naftopidil on bladder microcirculation in a rat model of bladder outlet obstruction / Low Urin Tract Symptoms 9:111~116
Okutsu H / 2010 / Effects of tamsulosin on bladder blood flow and bladder function in rats with bladder outlet obstruction / Urology 75:235~240
Abrams P / 2002 / The standardisation of terminology of lower urinary tract function:report from the Standardisation Sub-committee of the International Continence Society / Neurourol Urodyn 21:167~178
Caine M / 1990 / Alpha-adrenergic blockers for the treatment of benign prostatic hyperplasia / Urol Clin North Am 17:641~649
Majima T / 2017 / Effect of naftopidil on bladder microcirculation in a rat model of bladder outlet obstruction / Low Urin Tract Symptoms 9:111~116
Okutsu H / 2010 / Effects of tamsulosin on bladder blood flow and bladder function in rats with bladder outlet obstruction / Urology 75:235~240
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