지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제5호
- 발행연도
- 2018.9
- 수록면
- 539 - 546 (8page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.5.539
이용수
초록· 키워드
오류제보하기
Botulinum toxin type A (BoNT/A) has been used therapeutically for various conditions including dystonia, cerebral palsy, wrinkle, hyperhidrosis and pain control. The substantia gelatinosa (SG) neurons of the trigeminal subnucleus caudalis (Vc) receive orofacial nociceptive information from primary afferents and transmit the information to higher brain center. Although many studies have shown the analgesic effects of BoNT/A, the effects of BoNT/A at the central nervous system and the action mechanism are not well understood. Therefore, the effects of BoNT/A on the spontaneous postsynaptic currents (sPSCs) in the SG neurons were investigated. In whole cell voltage clamp mode, the frequency of sPSCs was increased in 18 (37.5%) neurons, decreased in 5 (10.4%) neurons and not affected in 25 (52.1%) of 48 neurons tested by BoNT/A (3 nM). Similar proportions of frequency variation of sPSCs were observed in 1 and 10 nM BoNT/A and no significant differences were observed in the relative mean frequencies of sPSCs among 1-10 nM BoNT/A. BoNT/A-induced frequency increase of sPSCs was not affected by pretreated tetrodotoxin (0.5 μM). In addition, the frequency of sIPSCs in the presence of CNQX (10 μM) and AP5 (20 μM) was increased in 10 (53%) neurons, decreased in 1 (5%) neuron and not affected in 8 (42%) of 19 neurons tested by BoNT/A (3 nM). These results demonstrate that BoNT/ A increases the frequency of sIPSCs on SG neurons of the Vc at least partly and can provide an evidence for rapid action of BoNT/A at the central nervous system.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Huang W / 2000 / Pharmacology of botulinum toxin / J Am Acad Dermatol 43:249~259
Pellizzari R / 1999 / Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses / Philos Trans R Soc Lond B Biol Sci 354:259~268
Simpson LL / 1981 / The origin, structure, and pharmacological activity of botulinum toxin / Pharmacol Rev 33:155~188
Peng Chen Z / 2012 / Emerging opportunities for serotypes of botulinum neurotoxins / Toxins (Basel) 4:1196~1222
Schiavo G / 2000 / Neurotoxins affecting neuroexocytosis / Physiol Rev 80:717~766
Pellizzari R / 1999 / Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses / Philos Trans R Soc Lond B Biol Sci 354:259~268
Simpson LL / 1981 / The origin, structure, and pharmacological activity of botulinum toxin / Pharmacol Rev 33:155~188
Peng Chen Z / 2012 / Emerging opportunities for serotypes of botulinum neurotoxins / Toxins (Basel) 4:1196~1222
Schiavo G / 2000 / Neurotoxins affecting neuroexocytosis / Physiol Rev 80:717~766
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