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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 260 - 267 (8page)
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Purpose: A major question remaining in approaches to tissue engineering and organ replacement is the role of native mobilized native cells in the regeneration process of damaged tissues and organs. The goal of this study was to compare the cell mobilizing effects of the chemokine CXCL12 and cell therapy on the urinary sphincter of nonhuman primates (NHP) with chronic intrinsic urinary sphincter dysfunction. Methods: Either autologous lenti-M-cherry labeled skeletal muscle precursor cells (skMPCs) or CXCL12 were injected directly into the sphincter complex of female NHPs with or without surgery-induced chronic urinary sphincter dysfunction (n=4/treatment condition). All monkeys had partial bone marrow transplantation with autologous lenti-green fluorescent protein (GFP) bone marrow cells prior to treatment. Labeled cells were identified, characterized and quantified using computer- assisted immunohistochemistry 6 months posttreatment. Results: GFP-labeled bone marrow cells (BMCs) were identified in the bone marrow and both BMCs and skMPCs were found in the urinary sphincter at 6-month postinjection. BMCs and skMPCs were present in the striated muscle, smooth muscle, and lamina propria/urothelium of the sphincter tissue. Sphincter injury increased the sphincter content of BMCs when analyzed 6-month postinjection. CXCL12 treatment, but not skMPCs, increased the number of BMCs in all layers of the sphincter complex (P<0.05). CXCL12 only modestly (P=0.15) increased the number of skMPCs in the sphincter complex. Conclusions: This dual labeling methodology now provides us with the tools to measure the relative number of locally injected cells versus bone marrow transplanted cells. The results of this study suggest that CXCL12 promotes mobilization of cells to the sphincter, which may contribute more to sphincter regeneration than injected cells.
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참고문헌 (13)
참고문헌 신청
Williams JK / 2017 / Determinates of muscle precursor cell therapy efficacy in a nonhuman primate model of intrinsic urinary sphincter deficiency / Stem Cell Res Ther 8:1
Liu S / 2016 / Strategies to optimize adult stem cell therapy for tissue regeneration / Int J Mol Sci 17
Syková E / 2006 / Magnetic resonance tracking of transplanted stem cells in rat brain and spinal cord / Neurodegener Dis 3:62~67
Jurgielewicz P / 2017 / New imaging probes to track cell fate: reporter genes in stem cell research / Cell Mol Life Sci 74:4455~4469
Williams JK / 2016 / Local versus intravenous injections of skeletal muscle precursor cells in nonhuman primates with acute or chronic intrinsic urinary sphincter deficiency / Stem Cell Res Ther 7:147
Liu S / 2016 / Strategies to optimize adult stem cell therapy for tissue regeneration / Int J Mol Sci 17
Syková E / 2006 / Magnetic resonance tracking of transplanted stem cells in rat brain and spinal cord / Neurodegener Dis 3:62~67
Jurgielewicz P / 2017 / New imaging probes to track cell fate: reporter genes in stem cell research / Cell Mol Life Sci 74:4455~4469
Williams JK / 2016 / Local versus intravenous injections of skeletal muscle precursor cells in nonhuman primates with acute or chronic intrinsic urinary sphincter deficiency / Stem Cell Res Ther 7:147
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