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논문 기본 정보

자료유형
학술저널
저자정보
J. Koudy Williams (Wake Forest Institute for Regenerative Medicine Winston-Salem) Karl-Erik Andersson (Division of Clinical Chemistry and Pharmacology Lund University) Shannon Lankford (Wake Forest Institute for Regenerative Medicine Winston-Salem) Gopal Badlani (Department of Urology Wake Forest Baptist Medical Center Winston-Salem)
저널정보
대한배뇨장애요실금학회 International Neurourology Journal International Neurourology Journal 제27권 제1호
발행연도
2023.3
수록면
55 - 62 (8page)
DOI
10.5213/inj.2244250.125

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Purpose: The relative roles of urinary sphincter damage, aging, and childbirth in stress urinary incontinence (SUI), have not been established. This study was performed to elucidate the roles of these factors. Methods: The study included: (1) 8 female cynomolgus monkeys (17–19 years of age and 7–8 vaginal births each); (2) six 5-year old nulliparous monkeys with surgically created chronic urinary sphincter dysfunction; and (3) six 5-year-old, nulliparous, no surgery controls. Sedated abdominal leak point pressure (ALPP) and maximum urethral sphincter pressures (MUP) were mea sured. Sphincters, bladders, and pelvic support muscles were quantified for collagen content. Additionally, bladders were ana lyzed for collagen fiber thickness, length, and angle using CT-FIRE analysis of Picrosirius red-stained tissues. Results: Resting MUP values were similar in the controls and older multiparous monkeys (P>0.05). However, aging and multi ple births reduced pudendal nerve-stimulated increases in MUP (P<0.05 vs. controls). ALPP values were lower in the older mul tiparous versus younger groups of monkeys (P<0.05). Sphincter collagen content was greater, and muscle content less, in the in jury model (P<0.05 vs. controls). However, these measures were not affected by age and childbirth (P>0.05 vs. young groups). Bladder collagen content was greater, and muscle content less, in the old multiparous monkeys (P<0.05 vs. younger groups). Ad ditionally, collagen fibers were thicker and more angular in the bladders of the older multiparous monkeys than in the other non human primate groups (P<0.05). Pelvic support muscles had higher collagen and lower muscle content in the older multiparous monkeys than in the younger groups of monkeys (P<0.05). Conclusions: SUI, associated with aging and multiple childbirths, appeared to be more strongly associated with bladder dys function, reduced pelvic muscle support, and the compensatory response to neural stimulation than with selective urinary sphincter dysfunction.

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