지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 270 - 281 (12page)
이용수
초록· 키워드
오류제보하기
Purpose: The aim of this study was to investigate urinary nerve growth factor (NGF) as a biomarker of treatment efficacy and recurrence in overactive bladder (OAB) patients.
Methods: We enrolled 189 OAB subjects who visited our outpatient clinic from February 2010 to February 2015. All subjects with OAB received antimuscarinic treatment. A 3-day voiding diary and questionnaire were collected from each patient. Urinary levels of NGF were evaluated at baseline, the beginning of antimuscarinic treatment, and the end of antimuscarinic treatment.
Urinary NGF was normalized to urine creatinine (Cr). Between-group comparisons of baseline characteristics were made using the Mann-Whitney U-test. Multivariate logistic regression analyses were used to predict responses to anticholinergic treatment and recurrence. The Wilcoxon signed-rank test with the Bonferroni correction was used for intragroup comparisons.
A receiver operating characteristic curve was used to analyze the utility of this biomarker.
Results: Urinary levels of NGF/Cr tended to decrease in patients who responded to treatment (n=62), but this was not significant (P=0.260). Urinary NGF levels were higher at baseline in patients who did not experience recurrence than in those who did (P=0.047). In those who did not experience recurrence (n=29), urinary NGF/Cr decreased at the end of treatment compared to baseline, and this reduction was maintained at 12 weeks after the end of treatment (P<0.05).
Conclusions: Urinary NGF is a potential biomarker for predicting the outcome of antimuscarinic treatment in OAB patients.
This may provide useful information when deciding to stop antimuscarinic treatment in responders.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Antunes-Lopes T / 2013 / Urinary neurotrophic factors in healthy individuals and patients with overactive bladder / J Urol 189 : 359 ~ 365
Bhide AA / 2013 / Biomarkers in overactive bladder / In
Choo MS / 2005 / Changes in overactive bladder symptoms after discontinuation of successful 3-month treatment with an antimuscarinic agent : a prospective trial / J Urol 174
Chuang YC / 2001 / The role of bladder afferent pathways in bladder hyperactivity induced by the intravesical administration of nerve growth factor / J Urol 165 : 975 ~ 979
Digesu GA / 2008 / Should we explain lower urinary tract symptoms to patients? / Neurourol Urodyn 27 : 368 ~ 371
Bhide AA / 2013 / Biomarkers in overactive bladder / In
Choo MS / 2005 / Changes in overactive bladder symptoms after discontinuation of successful 3-month treatment with an antimuscarinic agent : a prospective trial / J Urol 174
Chuang YC / 2001 / The role of bladder afferent pathways in bladder hyperactivity induced by the intravesical administration of nerve growth factor / J Urol 165 : 975 ~ 979
Digesu GA / 2008 / Should we explain lower urinary tract symptoms to patients? / Neurourol Urodyn 27 : 368 ~ 371
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Potential Biomarkers for Diagnosis of Overactive Bladder Patients: Urinary Nerve Growth Factor, Prostaglandin E2, and Adenosine Triphosphate
International Neurourology Journal
2017 .01
-
NGF and HB-EGF: Potential Biomarkers that Reflect the Effects of Fesoterodine in Patients with Overactive Bladder Syndrome
Yonsei Medical Journal
2015 .01
-
Factors affecting medication discontinuation in patients with overactive bladder symptoms
Obstetrics & Gynecology Science
2015 .01
-
Duration of Antimuscarinic Administration for Treatment of Overactive Bladder Before Which One Can Assess Efficacy: An Analysis of Predictive Factors
International Neurourology Journal
2015 .01
-
Efficacy and safety of dose escalation in male patients with overactive bladder showing poor efficacy after low-dose antimuscarinic treatment: A retrospective multicenter study
Investigative and Clinical Urology
2020 .01
-
과민성방광의 새로운 약물치료: 미라베그론과보툴리눔 독소
대한의사협회지
2016 .01
-
Intravesical Sodium Chondroitin Sulphate to Treat Overactive Bladder: Preliminary Result
International Neurourology Journal
2015 .01
-
Updates of Overactive Bladder in Pediatrics
International Neurourology Journal
2023 .03
-
Evaluation of the incidence and risk factors associated with persistent frequency in interstitial cystitis/bladder pain syndrome and the efficacy of antimuscarinic treatment
Investigative and Clinical Urology
2017 .01
-
Potential Role of Monocyte Chemoattractant Protein-1 in Monitoring Disease Progression and Response to Treatment in Overactive Bladder Patients
International Neurourology Journal
2020 .01
-
요실금과 과민성방광
대한의사협회지
2015 .01
-
Catheter Ablation of Atrial Fibrillation Raises the Plasma Level of NGF-β Which Is Associated with Sympathetic Nerve Activity
Yonsei Medical Journal
2015 .01
-
Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats
International Neurourology Journal
2016 .01
-
Relationship between Lower Urinary Tract Dysfunction and Dementia
Dementia and Neurocognitive Disorders(대한치매학회지)
2020 .01
-
Overactive Bladder Successfully Treated with Duloxetine in a Female Adolescent
Clinical Psychopharmacology and Neuroscience
2015 .01
-
Incidence and risk factors of recurrence of overactive bladder symptoms after discontinuation of successful medical treatment
Investigative and Clinical Urology
2017 .01
-
Practical Aspects of Botulinum Toxin-A Treatment in Patients With Overactive Bladder Syndrome
International Neurourology Journal
2015 .01
-
Drug therapy of overactive bladder - What is coming next?
Investigative and Clinical Urology
2015 .01
-
Assessment of Proportion of Hidden Patients Having Symptoms of Overactive Bladder and Why Has It Been Hidden in Female Outpatients Admitted to Hospital
International Neurourology Journal
2016 .01
-
Evaluation of Overactive Bladder in Male Antidepressant Users: A Prospective Study
International Neurourology Journal
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0