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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,282 - 1,285 (4page)
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To determine whether platelet-rich fibrin lysate (PRF-L) could restore the function of chronically ultraviolet-A (UVA)-irradiated human dermal fibroblasts (HDFs), we isolated and sub-cultured HDFs from six different human foreskins. HDFs were divided into two groups: those that received chronic UVA irradiation (total dosages of 10 J cm-2) and those that were not irradiated. We compared the proliferation rates, collagen deposition, and migration rates between the groups and between chronically UVA-irradiatedHDFs in control and PRF-L-treated media. Our experiment showed that chronic UVA irradiation significantly decreased (p<0.05) the proliferation rates, migration rates, and collagen deposition of HDFs, compared to controls. Compared to control media, chronically UVA-irradiated HDFs in 50% PRF-L had significantly increased proliferation rates, migration rates, and collagendeposition (p<0.05), and the migration rates and collagen deposition of chronically UVA-irradiated HDFs in 50% PRF-L were equal to those of normal fibroblasts. Based on this experiment, we concluded that PRF-L is a good candidate material for treating UVA-induced photoaging of skin, although the best method for its clinical application remains to be determined.
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참고문헌 (25)
참고문헌 신청
Harding KG / 2005 / Wound chronicity and fibroblast senescence--implications for treatment / Int Wound J 2:364~368
Clark RA / 2008 / Oxidative stress and “senescent” fibroblasts in non-healing wounds as potential therapeutic targets / J Invest Dermatol 128:2361~2364
Margolis DJ / 2009 / Phase I study of H5.020CMV.PDGF-beta to treat venous leg ulcer disease / Mol Ther 17:1822~1829
Czuwara-Ladykowska J / 2001 / Differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fibroblasts / Br J Dermatol 145:569~575
Pan DB / 2010 / Platelet-derived growth factor-BB inhibited p21(WAF1) expression partially through transforming growth factor-beta signalling system in vascular smooth muscle cell / Zhonghua Xin Xue Guan Bing Za Zhi 38:160~165
Clark RA / 2008 / Oxidative stress and “senescent” fibroblasts in non-healing wounds as potential therapeutic targets / J Invest Dermatol 128:2361~2364
Margolis DJ / 2009 / Phase I study of H5.020CMV.PDGF-beta to treat venous leg ulcer disease / Mol Ther 17:1822~1829
Czuwara-Ladykowska J / 2001 / Differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fibroblasts / Br J Dermatol 145:569~575
Pan DB / 2010 / Platelet-derived growth factor-BB inhibited p21(WAF1) expression partially through transforming growth factor-beta signalling system in vascular smooth muscle cell / Zhonghua Xin Xue Guan Bing Za Zhi 38:160~165
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