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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 551 - 557 (7page)
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초록· 키워드
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The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL- mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions.
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참고문헌 (28)
참고문헌 신청
/ / Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system : 28181 ~ 6
/ / Reactive oxygen intermediates activate NF- κB in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn t
/ 1995 / Identification and characterization of a new member of the TNF family that induces apoptosis 3 : 673 ~ 682
/ 1996 / Reactive oxygen species and programmed cell death 21 : 83 ~ 86
/ 1997 / An antagonist decoy receptor and a death domain-containing receptor for TRAIL 277 : 815 ~ 518
/ / Reactive oxygen intermediates activate NF- κB in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn t
/ 1995 / Identification and characterization of a new member of the TNF family that induces apoptosis 3 : 673 ~ 682
/ 1996 / Reactive oxygen species and programmed cell death 21 : 83 ~ 86
/ 1997 / An antagonist decoy receptor and a death domain-containing receptor for TRAIL 277 : 815 ~ 518
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Hydrogen peroxide enhances TRAIL-induced cell death through up-regulation of DR5 in human astrocytic cells
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TRAIL in Combination with Subtoxic 5-FU Effectively Inhibit Cell Proliferation and Induce Apoptosis in Cholangiocarcinoma Cells
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Ionizing Radiations Induce Apoptosis in TRAIL Resistant Cancer Cells: in vivo and in vitro Analysis
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Cell Cycle, Cell Death and Apoptosis
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Effect of Embelin on TRAIL Receptor 2 mAb-induced Apoptosis of TRAIL-resistant A549 Non-small Cell Lung Cancer Cells
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