지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 253 - 260 (8page)
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초록· 키워드
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Purpose: Methylenetetrahydrofolate reductase (MTHFR) is the main regulatory enzyme for homocysteine metabolism. In the present study, we evaluated whether the MTHFR 677C>T and 1298A>C gene polymorphisms are associated with SBI and plasma homocysteine concentration in a Korean population. Materials and Methods:We enrolled 264 patients with SBI and 234 healthy controls in South Korea. Fasting plasma total homocysteine (tHcy) concentrations were measured, and genotype analysis of the MTHFR gene was carried out. Results: The plasma tHcy levels were significantly higher in patients with SBI than in healthy controls. Despite a significant association between the MTHFR 677TT genotype and hyperhomocysteinemia, the MTHFR 677C>T genotypes did not appear to influence susceptibility to SBI. However, odds ratios of the 1298AC and 1298AC + CC genotypes for the 1298AA genotype were significantly different between SBI patients and normal controls. The frequencies of 677C-1298A and 677C-1298C haplotypes were significantly higher in the SBI group than in the control group.
Conclusion: This study demonstrates that the MTHFR 1298A>C polymorphism is a risk factor for SBI in a Korean population. The genotypes of 677C>T and 1298A>C polymorphisms interact additively, and increase the risk of SBI in Korean subjects.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bernick C / 2001 / Silent MRI infarcts and the risk of future stroke: the cardiovascualr health study / Neurology 57 : 1222 ~ 1229
Boushey CJ / 1995 / A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes / JAMA 274 : 10
Choi BO / 2003 / Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple small-artery occlusions / Thromb Res 111 : 39 ~ 44
Clarke R / 1991 / Hyperhomocysteinemia: an independent risk factor for vascular disease / N Engl J Med 324 : 1149 ~ 1155
Friedman G / 1999 / A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations / J Nutr
Boushey CJ / 1995 / A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes / JAMA 274 : 10
Choi BO / 2003 / Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple small-artery occlusions / Thromb Res 111 : 39 ~ 44
Clarke R / 1991 / Hyperhomocysteinemia: an independent risk factor for vascular disease / N Engl J Med 324 : 1149 ~ 1155
Friedman G / 1999 / A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations / J Nutr
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정신분열병 환자에서의 혈중 Homocysteine 농도와 MTHFR C677T, A1298C의 유전자 다형성
생물정신의학
2005 .01
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Influence of Combined Methionine Synthase (MTR 2756A>G) and Methylenetetrahydrofolate Reductase (MTHFR 677C>T) Polymorphisms to Plasma Homocysteine Levels in Korean Patients with Ischemic Stroke
Yonsei Medical Journal
2007 .01
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The Methylenetetrahydrofolate Reductase C677T Polymorphism Influences Risk of Esophageal Cancer in Chinese
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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5,10-Methylenetetrahydrofolate Reductase (MTHFR C677T와 A1298C) 유전자 돌연변이의 반복자연유산 관련성 연구
대한불임학회지
2002 .01
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Methylenetetrahydrofolate Reductase C677T, A1298C 그리고 G1793A 유전자 다형성과 위암 발생의 위험
Annals of Surgical Treatment and Research
2006 .07
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Allele and Genotype Frequencies of the Polymorphic Methylenetetrahydrofolate Reductase and Colorectal Cancer among Jordanian Population
Asian Pacific journal of cancer prevention : APJCP
2013 .01
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Methylenetetrahydrofolate Reductase(MTHFR) 유전자다형과 자연 유산아 발생의 관련성에 관한 연구
대한불임학회지
2006 .01
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Risk of thyroid and breast cancer associated with methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in Korea
대한임상종양학회 학술대회지
2012 .03
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Allele and Genotype Frequencies of the Polymorphic Methylenetetrahydrofolate Reductase and Lung Cancer in ther Jordanian Population: a Case Control Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Lung Cancer: an Updated Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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Evaluation of the MTHFR C677T Polymorphism as a Risk Factor for Colorectal Cancer in Asian Populations
Asian Pacific journal of cancer prevention : APJCP
2015 .01
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MTHFR C667T Polymorphism Association with Lung Cancer Risk in Henan Province: A Case-control Study
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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한국인 남성 불임 환자에서 5,10-Methylenetetrahydrofolate Reductase (MTHFR) 유전자의 1298번의 다형성과의 관련성에 관한 연구
대한불임학회지
2003 .01
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Folate Pathway Gene MTHFR C677T Polymorphism and Risk of Lung Cancer in Asian Populations
Asian Pacific journal of cancer prevention : APJCP
2014 .01
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한국인 다낭성 난포증후군 환자에서 5,10-Methylenetetrahydrofolate Reductase의 677번 유전자 다형성에 관한 연구
대한불임학회지
2003 .01
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Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population
Clinical and Experimental Pediatrics
2011 .01
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MTHFR C677T Polymorphism and Pancreatic Cancer Risk: a Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
2012 .01
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