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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 34 - 38 (5page)
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초록· 키워드
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Purpose: It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigatedthe effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identifytheir relation in the urothelium of the urinary bladder.
Methods: The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockoutmice urinary bladder, were examined by Western blot and immunofluorescence techniques.
Results: Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer inthe wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in thewild type controls (P<0.05).
Conclusions: The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity.
This might play a specific role in bladder dysfunction.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Araki I / 2004 / Overexpression of epithelial sodium channels in epithelium of human urinary bladder with outlet obstruction / Urology 64 : 1255 ~ 1260
Birder LA / 2007 / Mechanisms of disease: involvement of the urothelium in bladder dysfunction / Nat Clin Pract Urol 4 : 46 ~ 54
Cao G / 2003 / Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis / Am J Pathol 162 : 1241 ~ 1248
Cross WR / 2005 / A biomimetic tissue from cultured normal human urothelial cells: analysis of physiological function / Am J Physiol Renal Physiol 289 : F459 ~ F468
Gannon BJ / 2000 / Aquaporin-1 expression in visceral smooth muscle cells of female rat reproductive tract / J Smooth Muscle Res 36 : 155 ~ 167
Birder LA / 2007 / Mechanisms of disease: involvement of the urothelium in bladder dysfunction / Nat Clin Pract Urol 4 : 46 ~ 54
Cao G / 2003 / Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis / Am J Pathol 162 : 1241 ~ 1248
Cross WR / 2005 / A biomimetic tissue from cultured normal human urothelial cells: analysis of physiological function / Am J Physiol Renal Physiol 289 : F459 ~ F468
Gannon BJ / 2000 / Aquaporin-1 expression in visceral smooth muscle cells of female rat reproductive tract / J Smooth Muscle Res 36 : 155 ~ 167
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