지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 690 - 696 (7page)
- DOI
- https://doi.org/10.4111/icu.20210284
이용수
초록· 키워드
오류제보하기
Purpose: The purpose of this study was to investigate the effect of aging on bladder function and caveolin protein expression in rat urothelium.
Materials and Methods: Female Sprague-Dawley rats were divided into the following two groups: young age control group (12 weeks) and old-aged group of rats (80 weeks). Urodynamic measurements were taken to compare the contraction interval and the contraction pressure between the two groups. The expression and cellular localization of caveolin 1 and 2 in the urothelium of the rat urinary bladder were determined by Western blot and immunofluorescence microscopy.
Results: In cystometrograms, the contraction interval (min) was significantly shorter in the old-aged group (3.7±0.5 min) than in the young age control group (6.2±0.8 min). Also, the average contraction pressure (mmHg) was lower in the old-aged group (8.4±0.6 mmHg) than in the young age control group (13.2±1.3 mmHg). Caveolin 1 and 2 were expressed in the subepithelial area in the urothelium. The protein expression of both caveolin 1 and 2 was significantly lower in the old-aged group than in the young age control group.
Conclusions: Aging caused a significant change in the expression of caveolin 1 and 2 in the urothelium of the rat urinary bladder. These findings suggest that these molecules might have specific roles in the functional change of the urinary bladder that occurs in association with aging.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
de Groat WC / 2004 / The urothelium in overactive bladder: passive bystander or active participant? / Urology 64(6 Suppl 1):7~11
Birder LA / 2007 / Mechanisms of disease : involvement of the urothelium in bladder dysfunction / Nat Clin Pract Urol 4:46~54
Lin AD / 2006 / Estrogen induced functional hypertrophy and increased force generation of the female rabbit bladder / Neurourol Urodyn 25:473~479
Smart EJ / 1996 / A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane / J Biol Chem 271:29427~29435
Galbiati F / 2001 / Emerging themes in lipid rafts and caveolae / Cell 106:403~411
Birder LA / 2007 / Mechanisms of disease : involvement of the urothelium in bladder dysfunction / Nat Clin Pract Urol 4:46~54
Lin AD / 2006 / Estrogen induced functional hypertrophy and increased force generation of the female rabbit bladder / Neurourol Urodyn 25:473~479
Smart EJ / 1996 / A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane / J Biol Chem 271:29427~29435
Galbiati F / 2001 / Emerging themes in lipid rafts and caveolae / Cell 106:403~411
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice
International Neurourology Journal
2015 .01
-
Decreased Expression of Urethral Caveolin-1, -2, and -3 in the Rat Model of Overactive Bladder: Potential Mediator of Functional Interaction of Urethra and Urinary Bladder
International Neurourology Journal
2023 .03
-
Neonatal Bladder Irritation Is Associated With Vanilloid Receptor TRPV1 Expression in Adult Rats
International Neurourology Journal
2018 .01
-
Quantification of Aging-Related Decreases in Sensory Innervation of the Bladder Trigone in Rats
International Neurourology Journal
2024 .02
-
Electrical Activity of the Bladder Is Attenuated by Intravesical Inhibition of P2X2/3 Receptors During Micturition in Female Rats
International Neurourology Journal
2017 .01
-
Gender-related outcomes in robot-assisted radical cystectomy: A multi-institutional study
Investigative and Clinical Urology
2022 .01
-
The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats
The Korean Journal of Physiology & Pharmacology
2018 .09
-
Caveolin-1 is Up-regulated in the Aged Skin : Biomarker of Skin Aging
한국실험동물학회 학술발표대회 논문집
2015 .08
-
The purified extract of steamed Panax ginseng protects cardiomyocyte from ischemic injury via caveolin-1 phosphorylation-mediating calcium influx
Journal of Ginseng Research
2023 .11
-
Implantable Bladder Sensors: A Methodological Review
International Neurourology Journal
2015 .01
-
Structural Changes of the Urinary Bladder After Chronic Complete Spinal Cord Injury in Minipigs
International Neurourology Journal
2017 .01
-
In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats
International Neurourology Journal
2019 .01
-
ERRATUM: Caveolin-1 Modulates Docetaxel-Induced Cell Death in Breast Cancer Cell Subtypes through Different Mechanisms
Cancer Research and Treatment
2019 .01
-
Weakness of the Pelvic Floor Muscle and Bladder Neck Is Predicted by a Slight Rise in Abdominal Pressure During Bladder Filling: A Video Urodynamic Study in Children
International Neurourology Journal
2016 .01
-
Irreversible Bladder Remodeling Induced by Fibrosis
International Neurourology Journal
2021 .01
-
Implantable Bladder Sensors for Long-term Monitoring of Bladder Volume
International Neurourology Journal
2015 .01
-
Role of Nicotinic Acetylcholine Receptor α3 and α7 Subunits in Detrusor Overactivity Induced by Partial Bladder Outlet Obstruction in Rats
International Neurourology Journal
2015 .01
-
Expression of bladder α1-adrenoceptor subtype after relief of partial bladder outlet obstruction in a rat model
Investigative and Clinical Urology
2020 .01
-
The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis
International Neurourology Journal
2023 .03
-
Versatile Functions of Caveolin-1 in Aging-related Diseases
전남의대학술지
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0