지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 742 - 747 (6page)
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초록· 키워드
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Purpose: Non-steroidal anti-inflammatory drugs (NSAID) are frequently used in oral surgical procedures in dentistry. The evaluation of the frequency of sister chromatid exchange (SCE) is accepted as a reliable cytogenetic method to assess the genotoxic effects of environmental factors. Materials and Methods: In this study, the genotoxic effects of various NSAIDs were assessed in 30 patients to who they were administered following encluosed third molar surgery using SCE analysis before and after the operation. The frequency of SCE was evaluated before the operation and after 3 days of etodolac, nimesulid and naproxen use. Results: There was no statistically significant difference in the frequency of SCE between the preoperative and postoperative states in patients given etodolac, nimesulid or naproxen sodium. Conclusion: Short term use of selective and non-selective NSAIDs was not associated with a significant genotoxic effect that could be detected using the SCE method in peripheric lymphocytes.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Balfour JA / 1991 / Etodolac. A reappraisal of its pharmacology and therapeutic use in rheumatic diseases and pain states / Drugs 42 : 274 ~ 299
Barale R / 1998 / Sister chromatid exchange and micronucleus frequency in human lymphocytes of 1,650 subjects in an Italian population: II. Contribution of sex, age and life
Carbonell E / 1995 / SCE analysis in h
Carrano AV / 1978 / Sister chromatid exchange as an indicator for mutagenesis / Nature 271 : 551 ~ 553
Carrano AV / 1982 / The rationale methodology for quantifying sister-chromatid exchanges in humans / Academic Press : 267 ~ 304
Barale R / 1998 / Sister chromatid exchange and micronucleus frequency in human lymphocytes of 1,650 subjects in an Italian population: II. Contribution of sex, age and life
Carbonell E / 1995 / SCE analysis in h
Carrano AV / 1978 / Sister chromatid exchange as an indicator for mutagenesis / Nature 271 : 551 ~ 553
Carrano AV / 1982 / The rationale methodology for quantifying sister-chromatid exchanges in humans / Academic Press : 267 ~ 304
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