지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 200 - 205 (6page)
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초록· 키워드
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Purpose: Lithium-pilocarpine induced status epilepticus (LPSE) causes selective and age-dependent neuronal death,
although the mechanism of maturation-related injury has not yet been clarified. The activating transcription factor-2 (ATF-2)
protein is essential for the normal development of mammalian brain and is activated by c-Jun N-terminal kinase (JNK). It
induces the expression of the c-jun gene and modulates the function of the c-Jun protein, a mediator of neuronal death and
survival. Therefore, we investigated the expression of c-Jun and ATF-2 protein in the immature and adult rat hippocampus to
understand their roles in LPSE-induced neuronal death. Materials and Methods: Lithium chloride was administrated to
P10 and adult rats followed by pilocarpine. Neuronal injury was assessed by silver and cresyl violet staining, performed 72
hours after status epilepticus. For evaluation of the expression of ATF-2 and c-Jun by immunohistochemical method and
Western blot, animals were sacrificed at 0, 4, 24, and 72 hours after the initiation of seizure. Results: Neuronal injury and
expression of c-Jun were maturation-dependently increased by LPSE, whereas ATF-2 immunoreactivity decreased in the
mature brain. Since both c-Jun and ATF-2 are activated by JNK, and targets and competitors in the same signal transduction
cascade, we could speculate that ATF-2 may compete with c-Jun for JNK phosphorylation. Conclusion: The results
suggested a neuroprotective role of ATF-2 in this maturation-related evolution of neuronal cell death from status epilepticus.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
[학
Berger ML / 1984 / Maturation of kainic acid seizure-brain damage syndrome in the rat. III. Postnatal development of kainic acid binding sites in the limbic system / Neurosc
Cavalheiro EA / 1987 / The susceptibility of rats to pilocarpine-induced seizures is age-dependent / Brain Res 465 : 43 ~ 58
Cheung NS / 1998 / Giardina SF. Kainateinduced apoptosis correlates with c-Jun activation in cultured cerebellar granular cells / J Neurosci Res 52 : 69 ~ 82
De Bruin VM / 2000 / Behavioral and neurochemical alterations after lithium-pilocarpine administration in young and adult rats: a comparative study / Pharmacol Biochem Behav
Berger ML / 1984 / Maturation of kainic acid seizure-brain damage syndrome in the rat. III. Postnatal development of kainic acid binding sites in the limbic system / Neurosc
Cavalheiro EA / 1987 / The susceptibility of rats to pilocarpine-induced seizures is age-dependent / Brain Res 465 : 43 ~ 58
Cheung NS / 1998 / Giardina SF. Kainateinduced apoptosis correlates with c-Jun activation in cultured cerebellar granular cells / J Neurosci Res 52 : 69 ~ 82
De Bruin VM / 2000 / Behavioral and neurochemical alterations after lithium-pilocarpine administration in young and adult rats: a comparative study / Pharmacol Biochem Behav
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ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells
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흰쥐에서 고용량의 Pilocarpine에 의하여 유발된 간질중첩증의 양상
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