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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제56권 제3호
발행연도
2015.1
수록면
793 - 797 (5page)

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Purpose: Moyamoya disease (MMD) occurs predominantly in Korean and Japanesewomen. The aim of this study was to investigate clinical features and pregnancy outcomes in women with MMD. Materials and Methods: We conducted a retrospectivechart review of women with MMD who visited our Department of Obstetricsand Gynecology between January 2005 and October 2013. For all study subjects,clinical features, demographic characteristics, and perinatal outcomes were recorded. Results: We identified 28 pregnancies in 22 patients who had been diagnosedwith MMD. The mean maternal age at delivery was 31.9±3.5 years old. The mean gestational age at delivery was 38.0±0.9 weeks. Among the 28 pregnancies, 25 (92.5%) underwent cesarean section; 19 (76.0%) of them were performed under regionalanesthesia and six (24.0%) under general anesthesia. The mean newborn weight was 3233.7±348.2 g. The 5-minute Apgar score in 85% of the newborns was higher than 8, with no other apparent complications. During the puerperal period, transient ischemic attack symptom or seizure occurred in 4 cases, although patients recovered within a few days. Conclusion: For pregnant women with MMD, it is importantto control blood pressure and prevent hyperventilation during the intrapartum period, and the best methods of delivery and anesthesia should be considered to avoid unfavorable sequelae. Additionally, a multidisciplinary approach (i.e., neurosurgery)is necessary to constantly manage underlying diseases.

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