지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 676 - 683 (8page)
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초록· 키워드
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Purpose: Some patients with interstitial lung disease (ILD) related to connective tissue disease (CTD) have a delayed diagnosis of the underlying CTD when the ILD is categorized as idiopathic. In this study, we evaluated the frequency of myositisautoantibodies in patients diagnosed with idiopathic ILD and investigated the clinical significance stemming from the presence of the antibodies. Materials and Methods: A total 32 patients diagnosed with idiopathic ILD were enrolled in this study. We analyzed a panel of 11 myositis autoantibody specificities in the patients using a line blot immunoassay. Then, we divided them into myositis autoantibody-positive and -negative groups and compared the clinical features and laboratory data between the two groups. Results: Of the 32 idiopathic ILD patients, 12 patients had myositis autoantibodies encompassing 9 specificities, except for anti-Mi-2 and anti-PM-Scl 100 (12/32, 38%). Anti-synthetase autoantibodies including Jo-1, EJ, OJ, PL-7, and PL-12 were present in 7 patients (7/32, 22%). The group with myositis autoantibodies presented more frequently with the symptom of mechanic’s hand and showed abnormal pulmonary function test results with low forced vital capacity,diffusing capacity for carbon monoxide, total lung capacity, and high lactate dehydrogenasevalues in blood when compared with the group without myositis antibodies.
Conclusion: We strongly suggest that patients undergo an evaluation of myositis autoantibodies, if they are diagnosed with idiopathic ILD in the presence of clinical characteristics including mechanic’s hand, arthralgia, and autoantibodies which are insufficient to make a diagnosis of a specific CTD category.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
American Thoracic Society; European Respiratory Society / 2002 / This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was
Borchers AT / 2011 / Idiopathic pulmonary fibrosis-an epidemiological and pathological review / Clin Rev Allergy Immunol 40 : 117 ~ 134
Chen IJ / 2009 / Interstitial lung disease in polymyositis and dermatomyositis / Clin Rheumatol 28 : 639 ~ 646
Cruellas MG / 2013 / Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and derm
Fathi M / 2004 / Interstitial lung disease, a common manifestation of newly diagnosed polymyositis and dermatomyositis / Ann Rheum Dis 63 : 297 ~ 301
Borchers AT / 2011 / Idiopathic pulmonary fibrosis-an epidemiological and pathological review / Clin Rev Allergy Immunol 40 : 117 ~ 134
Chen IJ / 2009 / Interstitial lung disease in polymyositis and dermatomyositis / Clin Rheumatol 28 : 639 ~ 646
Cruellas MG / 2013 / Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and derm
Fathi M / 2004 / Interstitial lung disease, a common manifestation of newly diagnosed polymyositis and dermatomyositis / Ann Rheum Dis 63 : 297 ~ 301
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